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Substance P receptor-expressing neurons in the medullary and spinal dorsal horns projecting to the nucleus of the solitary tract in the rat
By using substance P receptor (SPR) immunofluorescence histochemistry combined with fluorescent retrograde labeling, we examined the distribution of the trigeminal and spinal neurons with SPR-like immunoreactivity (-LI) projecting to the nucleus of the solitary tract in the rat. After injection of F...
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| Published in: | Neuroscience research 1998-03, Vol.30 (3), p.213-218 |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c455t-73aa40002d4acab4037a285914a3fa17b5ce4693c47358753f40333aaf7696e3 |
| container_end_page | 218 |
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| container_title | Neuroscience research |
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| creator | Guan, Zhen-Long Ding, Yu-Qiang Li, Jin-Lian Lü, Bao-Zhen |
| description | By using substance P receptor (SPR) immunofluorescence histochemistry combined with fluorescent retrograde labeling, we examined the distribution of the trigeminal and spinal neurons with SPR-like immunoreactivity (-LI) projecting to the nucleus of the solitary tract in the rat. After injection of Fluoro-Gold (FG) into the nucleus of the solitary tract, FG-labeled neurons showing SPR-LI were mainly seen in lamina I of the medullary and spinal dorsal horns, lamina V and the lateral spinal nucleus of the spinal cord. The present results suggest that the trigeminal and spinal neurons with SPR-LI, especially those in lamina I, may be involved in the transmission of somatic and/or visceral nociceptive information from the medullary and spinal dorsal horns to the nucleus of the solitary tract. |
| doi_str_mv | 10.1016/S0168-0102(97)00131-4 |
| format | article |
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After injection of Fluoro-Gold (FG) into the nucleus of the solitary tract, FG-labeled neurons showing SPR-LI were mainly seen in lamina I of the medullary and spinal dorsal horns, lamina V and the lateral spinal nucleus of the spinal cord. The present results suggest that the trigeminal and spinal neurons with SPR-LI, especially those in lamina I, may be involved in the transmission of somatic and/or visceral nociceptive information from the medullary and spinal dorsal horns to the nucleus of the solitary tract.</description><subject>Animals</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medulla Oblongata - immunology</subject><subject>Medulla Oblongata - metabolism</subject><subject>Neurons - immunology</subject><subject>Neurons - metabolism</subject><subject>Nociception</subject><subject>Nucleus of the solitary tract</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Neurokinin-1 - analysis</subject><subject>Receptors, Neurokinin-1 - biosynthesis</subject><subject>Solitary Nucleus - cytology</subject><subject>Solitary Nucleus - immunology</subject><subject>Solitary Nucleus - metabolism</subject><subject>Spino-solitary tract</subject><subject>Substance P receptor</subject><subject>Trigeminal Caudal Nucleus - cytology</subject><subject>Trigeminal Caudal Nucleus - immunology</subject><subject>Trigeminal Caudal Nucleus - metabolism</subject><subject>Trigeminal Nucleus, Spinal - cytology</subject><subject>Trigeminal Nucleus, Spinal - immunology</subject><subject>Trigeminal Nucleus, Spinal - metabolism</subject><subject>Trigemino-solitary tract</subject><issn>0168-0102</issn><issn>1872-8111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFUctOHDEQtFAQWR6fgOQTSg4T7LG9Hp-iCCUBCQkkuFteTw8YzdoTtycK35CfjvcB11zcsrqqu6uKkHPOvnDGl5cP9ekaxln7yejPjHHBG3lAFrzTbdNxzj-QxTvkIzlGfGGMCSPFETkyyggh-IL8fZhXWFz0QO9pBg9TSbmBP1MGxBCfaIQ5p4g0RFqega6hn8fR5VfqYk9xCtGNtE8Za3lOuQKnnF7Alw23pC0nzn6EGWkatl9MYyibCSU7X94GZ1dOyeHgRoSzfT0hjz--P15dN7d3P2-uvt02XipVGi2ck1VK20vn3UoyoV3bKcOlE4PjeqU8yKURXmqhOq3EUCGikga9NEsQJ-RiN7Ze-msGLHYd0ENVFSHNaLXptGhVW4FqB_Q5IWYY7JTDul5uObObDOw2A7sx2BpttxlYWXnn-wXzqvr1ztqbXvtfd32oIn8HyBZ9gBpBH2oCxfYp_GfDP4MdmDA</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>Guan, Zhen-Long</creator><creator>Ding, Yu-Qiang</creator><creator>Li, Jin-Lian</creator><creator>Lü, Bao-Zhen</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>Substance P receptor-expressing neurons in the medullary and spinal dorsal horns projecting to the nucleus of the solitary tract in the rat</title><author>Guan, Zhen-Long ; Ding, Yu-Qiang ; Li, Jin-Lian ; Lü, Bao-Zhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-73aa40002d4acab4037a285914a3fa17b5ce4693c47358753f40333aaf7696e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medulla Oblongata - immunology</topic><topic>Medulla Oblongata - metabolism</topic><topic>Neurons - immunology</topic><topic>Neurons - metabolism</topic><topic>Nociception</topic><topic>Nucleus of the solitary tract</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Neurokinin-1 - analysis</topic><topic>Receptors, Neurokinin-1 - biosynthesis</topic><topic>Solitary Nucleus - cytology</topic><topic>Solitary Nucleus - immunology</topic><topic>Solitary Nucleus - metabolism</topic><topic>Spino-solitary tract</topic><topic>Substance P receptor</topic><topic>Trigeminal Caudal Nucleus - cytology</topic><topic>Trigeminal Caudal Nucleus - immunology</topic><topic>Trigeminal Caudal Nucleus - metabolism</topic><topic>Trigeminal Nucleus, Spinal - cytology</topic><topic>Trigeminal Nucleus, Spinal - immunology</topic><topic>Trigeminal Nucleus, Spinal - metabolism</topic><topic>Trigemino-solitary tract</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guan, Zhen-Long</creatorcontrib><creatorcontrib>Ding, Yu-Qiang</creatorcontrib><creatorcontrib>Li, Jin-Lian</creatorcontrib><creatorcontrib>Lü, Bao-Zhen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guan, Zhen-Long</au><au>Ding, Yu-Qiang</au><au>Li, Jin-Lian</au><au>Lü, Bao-Zhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Substance P receptor-expressing neurons in the medullary and spinal dorsal horns projecting to the nucleus of the solitary tract in the rat</atitle><jtitle>Neuroscience research</jtitle><addtitle>Neurosci Res</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>30</volume><issue>3</issue><spage>213</spage><epage>218</epage><pages>213-218</pages><issn>0168-0102</issn><eissn>1872-8111</eissn><abstract>By using substance P receptor (SPR) immunofluorescence histochemistry combined with fluorescent retrograde labeling, we examined the distribution of the trigeminal and spinal neurons with SPR-like immunoreactivity (-LI) projecting to the nucleus of the solitary tract in the rat. After injection of Fluoro-Gold (FG) into the nucleus of the solitary tract, FG-labeled neurons showing SPR-LI were mainly seen in lamina I of the medullary and spinal dorsal horns, lamina V and the lateral spinal nucleus of the spinal cord. The present results suggest that the trigeminal and spinal neurons with SPR-LI, especially those in lamina I, may be involved in the transmission of somatic and/or visceral nociceptive information from the medullary and spinal dorsal horns to the nucleus of the solitary tract.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>9593331</pmid><doi>10.1016/S0168-0102(97)00131-4</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Neuroscience research, 1998-03, Vol.30 (3), p.213-218 |
| issn | 0168-0102 1872-8111 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Animals Fluorescent Antibody Technique, Indirect Immunohistochemistry Male Medulla Oblongata - immunology Medulla Oblongata - metabolism Neurons - immunology Neurons - metabolism Nociception Nucleus of the solitary tract Rat Rats Rats, Wistar Receptors, Neurokinin-1 - analysis Receptors, Neurokinin-1 - biosynthesis Solitary Nucleus - cytology Solitary Nucleus - immunology Solitary Nucleus - metabolism Spino-solitary tract Substance P receptor Trigeminal Caudal Nucleus - cytology Trigeminal Caudal Nucleus - immunology Trigeminal Caudal Nucleus - metabolism Trigeminal Nucleus, Spinal - cytology Trigeminal Nucleus, Spinal - immunology Trigeminal Nucleus, Spinal - metabolism Trigemino-solitary tract |
| title | Substance P receptor-expressing neurons in the medullary and spinal dorsal horns projecting to the nucleus of the solitary tract in the rat |
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