Detection of a decarboxylated dimer of aminoethylcysteine ketimine in bovine cerebellum

Aminoethylcysteine ketimine is a sulfur-containing cyclic compound produced by the enzymatic α-deamination of the parent aminoethylcysteine that has been detected in bovine brain and cerebellum. Aminoethylcysteine ketimine is known to dimerize spontaneously and easily lose one carboxyl group. This d...

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Bibliographic Details
Published in:Neurochemistry international 1998-04, Vol.32 (4), p.365-368
Main Authors: Matarese, R.M., Macone, A., Crescentini, G., Duprè, S., Cavallini, D.
Format: Article
Language:English
Subjects:
Animals
Biochemistry and metabolism
Biological and medical sciences
Cattle
Central nervous system
Cerebellum - chemistry
Dimerization
Enzyme Inhibitors - analysis
Fundamental and applied biological sciences. Psychology
Gas Chromatography-Mass Spectrometry
Humans
Morpholines - analysis
Vertebrates: nervous system and sense organs
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Summary:Aminoethylcysteine ketimine is a sulfur-containing cyclic compound produced by the enzymatic α-deamination of the parent aminoethylcysteine that has been detected in bovine brain and cerebellum. Aminoethylcysteine ketimine is known to dimerize spontaneously and easily lose one carboxyl group. This decarboxylated compound, simply named the dimer, has been recently detected in normal human urine. In this article we provide evidence on the occurrence of the dimer in the bovine cerebellum.
ISSN:0197-0186
1872-9754
DOI:10.1016/S0197-0186(97)00094-6