Alternative Therapies for Neonatal Autoimmune Thrombocytopenia

Objective: This study was performed to test whether corticosteroids were superior to intravenous immunoglobulins (IVIG) in the treatment of neonatal autoimmune thrombocytopenia (NAT). Methods: All cases received IVIG, and unresponsive cases received corticosteroids. Results: Of 7 babies who received...

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Bibliographic Details
Published in:Vox sanguinis 1998-01, Vol.74 (3), p.198-200
Main Authors: Ovali, Fahri, Samanci, Nedim, Ermiş, Bahri, Akdoǧan, Zeliha, Daǧoǧlu, Türkan
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Adult
Autoimmune Diseases - immunology
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Cerebral Hemorrhage - prevention & control
Evaluation Studies as Topic
Female
Humans
Immunity, Maternally-Acquired
Immunoglobulin G - immunology
Immunoglobulins, Intravenous - therapeutic use
Immunosuppressive Agents - therapeutic use
Infant, Newborn
Medical sciences
Methylprednisolone - therapeutic use
Pharmacology. Drug treatments
Platelet Count
Pregnancy
Pregnancy Complications, Hematologic - immunology
Purpura, Thrombocytopenic, Idiopathic - immunology
Thrombocytopenia - congenital
Thrombocytopenia - etiology
Thrombocytopenia - therapy
Treatment Outcome
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Summary:Objective: This study was performed to test whether corticosteroids were superior to intravenous immunoglobulins (IVIG) in the treatment of neonatal autoimmune thrombocytopenia (NAT). Methods: All cases received IVIG, and unresponsive cases received corticosteroids. Results: Of 7 babies who received IVIG, only 1 responded. The 6 remaining cases received corticosteroids therafter, and all of them responded well to this therapy. Conclusions: Corticosteroids may be more effective than IVIG in NAT.
ISSN:0042-9007
1423-0410
DOI:10.1046/j.1423-0410.1998.7430198.x