The YGR194c ( XKS1) gene encodes the xylulokinase from the budding yeast Saccharomyces cerevisiae

We report the finding of a Saccharomyces cerevisiae gene necessary for growth in culture media with d-xylulose as the sole carbon source. This gene corresponds to the YGR194c open reading frame that we have previously described, and it is renamed now XKS1. Data bank comparisons of the protein encode...

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Bibliographic Details
Published in:FEMS microbiology letters 1998-05, Vol.162 (1), p.155-160
Main Authors: Rodriguez-Peña, Jose Manuel, Cid, Victor J, Arroyo, Javier, Nombela, Cesar
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Biological and medical sciences
Chromosome VII
Cloning, Molecular
Fundamental and applied biological sciences. Psychology
genbank/x82408
Gene Expression
Genes, Fungal - genetics
Growth, nutrition, metabolism, transports, enzymes. Molecular biology
Microbiology
Molecular Sequence Data
Mycology
Open Reading Frames
Phosphotransferases (Alcohol Group Acceptor) - genetics
Phosphotransferases (Alcohol Group Acceptor) - physiology
plant biochemistry
plant breeding
plant genetics
plant physiology
Saccharomyces cerevisiae
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - growth & development
Sequence Deletion
Sequence Homology, Amino Acid
Xylulokinase
Xylulose
Xylulose - metabolism
YGR194c
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Summary:We report the finding of a Saccharomyces cerevisiae gene necessary for growth in culture media with d-xylulose as the sole carbon source. This gene corresponds to the YGR194c open reading frame that we have previously described, and it is renamed now XKS1. Data bank comparisons of the protein encoded by the XKS1 gene showed significant homology with different xylulokinases, indicating a possible role in xylulose phosphorylation. The wild-type gene in a centromeric plasmid complemented defective growth of xks1 S. cerevisiae mutant strains in xylulose. By contrast, overexpression negatively influenced cell growth in this carbon source.
ISSN:0378-1097
1574-6968
DOI:10.1016/S0378-1097(98)00118-9