Methyl Chloride Transferase: A Carbocation Route for Biosynthesis of Halometabolites

Enzymatic synthesis of methyl halides through an S-adenosyl methionine transfer mechanism has been detected in cell extracts of Phellinus promaceus (a white rot fungus), Endocladia muricata (a marine red algae), and Mesembryanthemum crystallium (ice plant). This mechanism represents a novel pathway...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1990-07, Vol.249 (4965), p.160-162
Main Authors: Wuosmaa, Anne Marie, Hager, Lowell P.
Format: Article
Language:English
Subjects:
Algae
Analysis
atmospheric gases
Basidiomycota - enzymology
biosynthesis
Bromides
Bromides - metabolism
Cell extracts
Chlorides
Chlorides - metabolism
Chromatography, High Pressure Liquid
Endocladia muricata
enzymatic activity
Enzymes
Gas samples
Halides
halogenation
Hydrogen-Ion Concentration
Ice
Iodides
Iodides - metabolism
Marine algae
marine organisms
Mesembryanthemum crystallium
metabolic pathways
Methyl Chloride - metabolism
methyl chloride transferase
Methylation
Methyltransferases
Methyltransferases - isolation & purification
Methyltransferases - metabolism
Microbiological synthesis
Molecular Weight
Phellinus promaceus
Phosphates
Plants - enzymology
Rhodophyta - enzymology
Water Microbiology
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Summary:Enzymatic synthesis of methyl halides through an S-adenosyl methionine transfer mechanism has been detected in cell extracts of Phellinus promaceus (a white rot fungus), Endocladia muricata (a marine red algae), and Mesembryanthemum crystallium (ice plant). This mechanism represents a novel pathway for the formation of halometabolites. The Michaelis constants for chloride and bromide ion and for S-adenosyl methionine in the reaction have been determined for the enzyme from E. muricata. A recent survey of marine algae indicates that there may be a broad distribution of this enzyme among marine algae.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2371563