Micacocidin A, B and C, Novel Antimycoplasma Agents from Pseudomonas sp: II. Structure Elucidation

Metal-containing novel heterocyclic antibiotics, micacocidin A (1), B (2), and C (3) have been isolated from the culture filtrate of Pseudomonas sp. No. 57-250. The structure and absolute configuration of micacocidin A, an octahedral Zn2+ complex, was determined by X-ray crystallographic analysis. A...

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Bibliographic Details
Published in:Journal of antibiotics 1998/03/25, Vol.51(3), pp.328-332
Main Authors: KOBAYASHI, SHINOBU, NAKAI, HIROSHI, IKENISHI, YUJI, SUN, WEI-YIN, OZAKI, MAMORU, HAYASE, YOSHIO, TAKEDA, REIJI
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Antibacterial agents
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Applied microbiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Microbiology
Mycoplasma
Mycoplasma - drug effects
Organometallic Compounds - chemistry
Pharmacology. Drug treatments
Pseudomonas
Pseudomonas - metabolism
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Summary:Metal-containing novel heterocyclic antibiotics, micacocidin A (1), B (2), and C (3) have been isolated from the culture filtrate of Pseudomonas sp. No. 57-250. The structure and absolute configuration of micacocidin A, an octahedral Zn2+ complex, was determined by X-ray crystallographic analysis. And then, the structures of the two congeners, micacocidin B (Cu2+ complex) and C (Fe3+ complex) were investigated by employing one dimensional and two dimensional homonuclear and heteronuclear NMR spectroscopies and mass spectrometry.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.51.328