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Near-infrared spectrophotometry determined brain oxygenation during fainting
During orthostatic hypotension we evaluated whether presyncopal symptoms relate to a reduced brain oxygenation. Nine subjects performed 50° head‐up tilt for 1 h and eight subjects were followed during 2 h of supine rest and during 1 h of 10° head‐down tilt. Cerebral perfusion was assessed by transcr...
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| Published in: | Acta physiologica Scandinavica 1998-03, Vol.162 (4), p.501-507 |
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| cites | cdi_FETCH-LOGICAL-c4978-a794d6dcdfd9c07a2b1ba267438192f1918873d0771306a5e02b3bdc876538a53 |
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| container_title | Acta physiologica Scandinavica |
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| creator | MADSEN, P POTT, F OLSEN, S. B NIELSEN, H. B BURCEV, I SECHER, N. H |
| description | During orthostatic hypotension we evaluated whether presyncopal symptoms relate to a reduced brain oxygenation. Nine subjects performed 50° head‐up tilt for 1 h and eight subjects were followed during 2 h of supine rest and during 1 h of 10° head‐down tilt. Cerebral perfusion was assessed by transcranial Doppler determined middle cerebral artery blood velocity (MCA vmean), while brain blood oxygenation was assessed by near‐infrared spectrophotometry determined concentration changes for oxygenated (ΔHbO2) and deoxygenated haemoglobin and brain cell oxygenation by the oxidized cytochrome c concentration (ΔCytO2). During head‐up tilt, six volunteers developed presyncopal symptoms and mean arterial pressure (88 (78–103) to 68 (57–79) mmHg; median and range), heart rate (96 (72–111) to 65 (50–107) beats min−1), MCA vmean (59 (51–82) to 41 (29–56) cm s−1), ΔHbO2 (by −5.3 (−3.0 to −14.8) μmol l−1) and ΔCytO2 were reduced (by −0.2 (−0.1 to −0.4) μmol l−1; P |
| doi_str_mv | 10.1046/j.1365-201X.1998.0308f.x |
| format | article |
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B ; NIELSEN, H. B ; BURCEV, I ; SECHER, N. H</creator><creatorcontrib>MADSEN, P ; POTT, F ; OLSEN, S. B ; NIELSEN, H. B ; BURCEV, I ; SECHER, N. H</creatorcontrib><description>During orthostatic hypotension we evaluated whether presyncopal symptoms relate to a reduced brain oxygenation. Nine subjects performed 50° head‐up tilt for 1 h and eight subjects were followed during 2 h of supine rest and during 1 h of 10° head‐down tilt. Cerebral perfusion was assessed by transcranial Doppler determined middle cerebral artery blood velocity (MCA vmean), while brain blood oxygenation was assessed by near‐infrared spectrophotometry determined concentration changes for oxygenated (ΔHbO2) and deoxygenated haemoglobin and brain cell oxygenation by the oxidized cytochrome c concentration (ΔCytO2). During head‐up tilt, six volunteers developed presyncopal symptoms and mean arterial pressure (88 (78–103) to 68 (57–79) mmHg; median and range), heart rate (96 (72–111) to 65 (50–107) beats min−1), MCA vmean (59 (51–82) to 41 (29–56) cm s−1), ΔHbO2 (by −5.3 (−3.0 to −14.8) μmol l−1) and ΔCytO2 were reduced (by −0.2 (−0.1 to −0.4) μmol l−1; P < 0.05). During tilt down the cardiovascular variables recovered immediately and ΔHbO2 increased to 2.2 (−0.9–12.0) mmol L−1 above the resting value and also ΔCytO2 recovered. In the nonsyncopal head‐up tilted subjects as in the controls, blood pressure, heart rate, MCA vmean and brain oxygenation indices remained stable. The results suggest that during orthostasis, presyncopal symptoms relate not only to cerebral hypoperfusion but also to reduced brain oxygenation.</description><identifier>ISSN: 0001-6772</identifier><identifier>EISSN: 1365-201X</identifier><identifier>DOI: 10.1046/j.1365-201X.1998.0308f.x</identifier><identifier>PMID: 9597118</identifier><identifier>CODEN: APSCAX</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>Adult ; Biological and medical sciences ; Blood Flow Velocity - physiology ; Blood Pressure ; Brain - blood supply ; Brain - metabolism ; central venous pressure ; Cerebral Arteries - physiology ; cerebral blood flow ; electrical impedance ; Female ; Head-Down Tilt - physiology ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hemodynamics - physiology ; Humans ; hypotension ; Male ; Medical sciences ; Middle Aged ; near-infrared spectroscopy ; Nervous system (semeiology, syndromes) ; Neurology ; Oxygen - blood ; Oxygen Consumption ; Space life sciences ; Spectrophotometry, Infrared - methods ; Syncope - metabolism ; Tilt-Table Test - methods ; transcranial Doppler ; vaso-vagal syncope ; venous oxygen saturation</subject><ispartof>Acta physiologica Scandinavica, 1998-03, Vol.162 (4), p.501-507</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4978-a794d6dcdfd9c07a2b1ba267438192f1918873d0771306a5e02b3bdc876538a53</citedby><cites>FETCH-LOGICAL-c4978-a794d6dcdfd9c07a2b1ba267438192f1918873d0771306a5e02b3bdc876538a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2250304$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9597118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MADSEN, P</creatorcontrib><creatorcontrib>POTT, F</creatorcontrib><creatorcontrib>OLSEN, S. B</creatorcontrib><creatorcontrib>NIELSEN, H. B</creatorcontrib><creatorcontrib>BURCEV, I</creatorcontrib><creatorcontrib>SECHER, N. H</creatorcontrib><title>Near-infrared spectrophotometry determined brain oxygenation during fainting</title><title>Acta physiologica Scandinavica</title><addtitle>Acta Physiol Scand</addtitle><description>During orthostatic hypotension we evaluated whether presyncopal symptoms relate to a reduced brain oxygenation. Nine subjects performed 50° head‐up tilt for 1 h and eight subjects were followed during 2 h of supine rest and during 1 h of 10° head‐down tilt. Cerebral perfusion was assessed by transcranial Doppler determined middle cerebral artery blood velocity (MCA vmean), while brain blood oxygenation was assessed by near‐infrared spectrophotometry determined concentration changes for oxygenated (ΔHbO2) and deoxygenated haemoglobin and brain cell oxygenation by the oxidized cytochrome c concentration (ΔCytO2). During head‐up tilt, six volunteers developed presyncopal symptoms and mean arterial pressure (88 (78–103) to 68 (57–79) mmHg; median and range), heart rate (96 (72–111) to 65 (50–107) beats min−1), MCA vmean (59 (51–82) to 41 (29–56) cm s−1), ΔHbO2 (by −5.3 (−3.0 to −14.8) μmol l−1) and ΔCytO2 were reduced (by −0.2 (−0.1 to −0.4) μmol l−1; P < 0.05). During tilt down the cardiovascular variables recovered immediately and ΔHbO2 increased to 2.2 (−0.9–12.0) mmol L−1 above the resting value and also ΔCytO2 recovered. In the nonsyncopal head‐up tilted subjects as in the controls, blood pressure, heart rate, MCA vmean and brain oxygenation indices remained stable. The results suggest that during orthostasis, presyncopal symptoms relate not only to cerebral hypoperfusion but also to reduced brain oxygenation.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - physiology</subject><subject>Blood Pressure</subject><subject>Brain - blood supply</subject><subject>Brain - metabolism</subject><subject>central venous pressure</subject><subject>Cerebral Arteries - physiology</subject><subject>cerebral blood flow</subject><subject>electrical impedance</subject><subject>Female</subject><subject>Head-Down Tilt - physiology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>hypotension</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>near-infrared spectroscopy</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Oxygen - blood</subject><subject>Oxygen Consumption</subject><subject>Space life sciences</subject><subject>Spectrophotometry, Infrared - methods</subject><subject>Syncope - metabolism</subject><subject>Tilt-Table Test - methods</subject><subject>transcranial Doppler</subject><subject>vaso-vagal syncope</subject><subject>venous oxygen saturation</subject><issn>0001-6772</issn><issn>1365-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqNkEtLAzEUhYMoWh8_QZiFuJsxj5k8Fi6KaKuUKqjoLmSSjKbOoyZTbP-9qS1du7qPc8698AGQIJghmNOrWYYILVIM0XuGhOAZJJBX2XIPDHbCPhhACFFKGcNH4DiEWRwJx_gQHIpCMIT4AEymVvnUtZVX3pokzK3ufTf_7Pqusb1fJcb21jeujWLplWuTbrn6sK3qXdcmZuFd-5FUcd_H5hQcVKoO9mxbT8Dr3e3LzTidPI7ub4aTVOeC8VQxkRtqtKmM0JApXKJSYcpywpHAFRKIc0YMZAwRSFVhIS5JaTRntCBcFeQEXG7uzn33vbChl40L2ta1am23CJIJzoscimjkG6P2XQjeVnLuXaP8SiIo1yDlTK55yTUvuQYp_0DKZYyeb38sysaaXXBLLuoXW10FrerIr9Uu7GwYF_FSHm3XG9uPq-3q3-_l8Gk8jG3Mp5u8C71d7vLKf0nKCCvk23QkR9MX-vxA3yQjv0NYnx0</recordid><startdate>199803</startdate><enddate>199803</enddate><creator>MADSEN, P</creator><creator>POTT, F</creator><creator>OLSEN, S. B</creator><creator>NIELSEN, H. B</creator><creator>BURCEV, I</creator><creator>SECHER, N. H</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199803</creationdate><title>Near-infrared spectrophotometry determined brain oxygenation during fainting</title><author>MADSEN, P ; POTT, F ; OLSEN, S. B ; NIELSEN, H. B ; BURCEV, I ; SECHER, N. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4978-a794d6dcdfd9c07a2b1ba267438192f1918873d0771306a5e02b3bdc876538a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - physiology</topic><topic>Blood Pressure</topic><topic>Brain - blood supply</topic><topic>Brain - metabolism</topic><topic>central venous pressure</topic><topic>Cerebral Arteries - physiology</topic><topic>cerebral blood flow</topic><topic>electrical impedance</topic><topic>Female</topic><topic>Head-Down Tilt - physiology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>hypotension</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>near-infrared spectroscopy</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Oxygen - blood</topic><topic>Oxygen Consumption</topic><topic>Space life sciences</topic><topic>Spectrophotometry, Infrared - methods</topic><topic>Syncope - metabolism</topic><topic>Tilt-Table Test - methods</topic><topic>transcranial Doppler</topic><topic>vaso-vagal syncope</topic><topic>venous oxygen saturation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MADSEN, P</creatorcontrib><creatorcontrib>POTT, F</creatorcontrib><creatorcontrib>OLSEN, S. B</creatorcontrib><creatorcontrib>NIELSEN, H. B</creatorcontrib><creatorcontrib>BURCEV, I</creatorcontrib><creatorcontrib>SECHER, N. H</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta physiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MADSEN, P</au><au>POTT, F</au><au>OLSEN, S. B</au><au>NIELSEN, H. B</au><au>BURCEV, I</au><au>SECHER, N. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Near-infrared spectrophotometry determined brain oxygenation during fainting</atitle><jtitle>Acta physiologica Scandinavica</jtitle><addtitle>Acta Physiol Scand</addtitle><date>1998-03</date><risdate>1998</risdate><volume>162</volume><issue>4</issue><spage>501</spage><epage>507</epage><pages>501-507</pages><issn>0001-6772</issn><eissn>1365-201X</eissn><coden>APSCAX</coden><abstract>During orthostatic hypotension we evaluated whether presyncopal symptoms relate to a reduced brain oxygenation. Nine subjects performed 50° head‐up tilt for 1 h and eight subjects were followed during 2 h of supine rest and during 1 h of 10° head‐down tilt. Cerebral perfusion was assessed by transcranial Doppler determined middle cerebral artery blood velocity (MCA vmean), while brain blood oxygenation was assessed by near‐infrared spectrophotometry determined concentration changes for oxygenated (ΔHbO2) and deoxygenated haemoglobin and brain cell oxygenation by the oxidized cytochrome c concentration (ΔCytO2). During head‐up tilt, six volunteers developed presyncopal symptoms and mean arterial pressure (88 (78–103) to 68 (57–79) mmHg; median and range), heart rate (96 (72–111) to 65 (50–107) beats min−1), MCA vmean (59 (51–82) to 41 (29–56) cm s−1), ΔHbO2 (by −5.3 (−3.0 to −14.8) μmol l−1) and ΔCytO2 were reduced (by −0.2 (−0.1 to −0.4) μmol l−1; P < 0.05). During tilt down the cardiovascular variables recovered immediately and ΔHbO2 increased to 2.2 (−0.9–12.0) mmol L−1 above the resting value and also ΔCytO2 recovered. In the nonsyncopal head‐up tilted subjects as in the controls, blood pressure, heart rate, MCA vmean and brain oxygenation indices remained stable. The results suggest that during orthostasis, presyncopal symptoms relate not only to cerebral hypoperfusion but also to reduced brain oxygenation.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>9597118</pmid><doi>10.1046/j.1365-201X.1998.0308f.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Acta physiologica Scandinavica, 1998-03, Vol.162 (4), p.501-507 |
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| subjects | Adult Biological and medical sciences Blood Flow Velocity - physiology Blood Pressure Brain - blood supply Brain - metabolism central venous pressure Cerebral Arteries - physiology cerebral blood flow electrical impedance Female Head-Down Tilt - physiology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hemodynamics - physiology Humans hypotension Male Medical sciences Middle Aged near-infrared spectroscopy Nervous system (semeiology, syndromes) Neurology Oxygen - blood Oxygen Consumption Space life sciences Spectrophotometry, Infrared - methods Syncope - metabolism Tilt-Table Test - methods transcranial Doppler vaso-vagal syncope venous oxygen saturation |
| title | Near-infrared spectrophotometry determined brain oxygenation during fainting |
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