The role of antidiuretic hormone in cold-induced diuresis in the anaesthetized rat

The aim of this study was to investigate whether the increased diuresis in consequence of hypothermia is due to a depression of the hypothalamic release of antidiuretic hormone (ADH). The plasma concentration of antidiuretic hormone and the effect of intravenous (i.v.) administration of 65 ng kg−1 d...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 1998-04, Vol.162 (4), p.475-480
Main Authors: BROMAN, M, KÄLLSKOG, Ö, NYGREN, K, WOLGAST, M
Format: Article
Language:English
Subjects:
Anesthesia
Animals
antidiuretic hormone
arginine vasopressin
Biological and medical sciences
Blood Pressure - drug effects
Cold Temperature
Deamino Arginine Vasopressin - pharmacology
desmopressin
diuresis
Diuresis - drug effects
Diuresis - physiology
Fundamental and applied biological sciences. Psychology
Glomerular Filtration Rate - drug effects
Hormones and neuropeptides. Regulation
Hypothalamus. Hypophysis. Epiphysis. Urophysis
hypothermia
Hypothermia - physiopathology
Injections, Intraperitoneal
kidney
Kidney - physiopathology
Male
Osmolar Concentration
rat
Rats
Rats, Sprague-Dawley
Receptors, Vasopressin - agonists
V2 receptor
Vasopressins - physiology
Vertebrates: endocrinology
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Summary:The aim of this study was to investigate whether the increased diuresis in consequence of hypothermia is due to a depression of the hypothalamic release of antidiuretic hormone (ADH). The plasma concentration of antidiuretic hormone and the effect of intravenous (i.v.) administration of 65 ng kg−1 desmopressin (selective V2‐receptor agonist) were determined in the anaesthetized rat. In spite of a 50% (P 
ISSN:0001-6772
1365-201X
DOI:10.1046/j.1365-201X.1998.0314f.x