The Importance of Leukotrienes in Mast Cell-Mediated Toxoplasma gondii Cytotoxicity

Mast cells participate in the host defense against parasites. Mast cells release leukotrienes (LTs), potent 5-lipoxygenase (LO) products of arachidonic acid well-known to be involved in the inflammatory process. After incubation with Toxoplasma gondii, mast cells were found to degranulate and releas...

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Bibliographic Details
Published in:The Journal of infectious diseases 1998-05, Vol.177 (5), p.1437-1443
Main Authors: Henderson, William R., Chi, Emil Y.
Format: Article
Language:English
Subjects:
A-63162
Acetamides - pharmacology
Analysis of the immune response. Humoral and cellular immunity
Animals
Arachidonate 5-Lipoxygenase - metabolism
Biological and medical sciences
Cell Adhesion
Cells, Cultured
Concise Communications
Cytotoxicity
Eicosanoids
Enzyme Activation
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Histamines
Immunobiology
Indoles - pharmacology
indomethacin
leukotriene B4
Leukotriene B4 - biosynthesis
Leukotrienes
Leukotrienes - biosynthesis
Leukotrienes - physiology
Lipoxygenase Inhibitors - pharmacology
Macrophages
Male
Mast cells
Mast Cells - parasitology
Mast Cells - physiology
Mast Cells - ultrastructure
Microscopy, Electron
MK-886
Organs and cells involved in the immune response
Parasite hosts
Parasites
Phenyl Ethers
Rats
Rats, Sprague-Dawley
Reactive oxygen species
Tachyzoites
Toxoplasma - drug effects
Toxoplasma - physiology
Toxoplasma - ultrastructure
Toxoplasma gondii
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Description
Summary:Mast cells participate in the host defense against parasites. Mast cells release leukotrienes (LTs), potent 5-lipoxygenase (LO) products of arachidonic acid well-known to be involved in the inflammatory process. After incubation with Toxoplasma gondii, mast cells were found to degranulate and release LTB4; this interaction damages the tachyzoites. This mast cell activity against the tachyzoites was inhibited by the 5-LO inhibitor A-63162 and the 5-LO-activating protein inhibitor MK-886 but not by the cyclooxygenase inhibitor indomethacin. Reactive oxygen species were not implicated in the mast cell-mediated toxoplasmacidal activity. The generation of LTs is important for mast cell secretion, and LTB4 released by mast cells and other inflammatory cells may be a key factor in the host defense against T. gondii.
ISSN:0022-1899
1537-6613
DOI:10.1086/517833