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The Importance of Leukotrienes in Mast Cell-Mediated Toxoplasma gondii Cytotoxicity
Mast cells participate in the host defense against parasites. Mast cells release leukotrienes (LTs), potent 5-lipoxygenase (LO) products of arachidonic acid well-known to be involved in the inflammatory process. After incubation with Toxoplasma gondii, mast cells were found to degranulate and releas...
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| Published in: | The Journal of infectious diseases 1998-05, Vol.177 (5), p.1437-1443 |
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| Main Authors: | , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c396t-f8011c27bd889b5d4db386358c22287a862f760789a22da8ff3e8248c796ac243 |
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| container_end_page | 1443 |
| container_issue | 5 |
| container_start_page | 1437 |
| container_title | The Journal of infectious diseases |
| container_volume | 177 |
| creator | Henderson, William R. Chi, Emil Y. |
| description | Mast cells participate in the host defense against parasites. Mast cells release leukotrienes (LTs), potent 5-lipoxygenase (LO) products of arachidonic acid well-known to be involved in the inflammatory process. After incubation with Toxoplasma gondii, mast cells were found to degranulate and release LTB4; this interaction damages the tachyzoites. This mast cell activity against the tachyzoites was inhibited by the 5-LO inhibitor A-63162 and the 5-LO-activating protein inhibitor MK-886 but not by the cyclooxygenase inhibitor indomethacin. Reactive oxygen species were not implicated in the mast cell-mediated toxoplasmacidal activity. The generation of LTs is important for mast cell secretion, and LTB4 released by mast cells and other inflammatory cells may be a key factor in the host defense against T. gondii. |
| doi_str_mv | 10.1086/517833 |
| format | article |
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Mast cells release leukotrienes (LTs), potent 5-lipoxygenase (LO) products of arachidonic acid well-known to be involved in the inflammatory process. After incubation with Toxoplasma gondii, mast cells were found to degranulate and release LTB4; this interaction damages the tachyzoites. This mast cell activity against the tachyzoites was inhibited by the 5-LO inhibitor A-63162 and the 5-LO-activating protein inhibitor MK-886 but not by the cyclooxygenase inhibitor indomethacin. Reactive oxygen species were not implicated in the mast cell-mediated toxoplasmacidal activity. The generation of LTs is important for mast cell secretion, and LTB4 released by mast cells and other inflammatory cells may be a key factor in the host defense against T. gondii.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/517833</identifier><identifier>PMID: 9593043</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>A-63162 ; Acetamides - pharmacology ; Analysis of the immune response. Humoral and cellular immunity ; Animals ; Arachidonate 5-Lipoxygenase - metabolism ; Biological and medical sciences ; Cell Adhesion ; Cells, Cultured ; Concise Communications ; Cytotoxicity ; Eicosanoids ; Enzyme Activation ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Histamines ; Immunobiology ; Indoles - pharmacology ; indomethacin ; leukotriene B4 ; Leukotriene B4 - biosynthesis ; Leukotrienes ; Leukotrienes - biosynthesis ; Leukotrienes - physiology ; Lipoxygenase Inhibitors - pharmacology ; Macrophages ; Male ; Mast cells ; Mast Cells - parasitology ; Mast Cells - physiology ; Mast Cells - ultrastructure ; Microscopy, Electron ; MK-886 ; Organs and cells involved in the immune response ; Parasite hosts ; Parasites ; Phenyl Ethers ; Rats ; Rats, Sprague-Dawley ; Reactive oxygen species ; Tachyzoites ; Toxoplasma - drug effects ; Toxoplasma - physiology ; Toxoplasma - ultrastructure ; Toxoplasma gondii</subject><ispartof>The Journal of infectious diseases, 1998-05, Vol.177 (5), p.1437-1443</ispartof><rights>Copyright 1998 University of Chicago</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-f8011c27bd889b5d4db386358c22287a862f760789a22da8ff3e8248c796ac243</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30108178$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30108178$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2250499$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9593043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henderson, William R.</creatorcontrib><creatorcontrib>Chi, Emil Y.</creatorcontrib><title>The Importance of Leukotrienes in Mast Cell-Mediated Toxoplasma gondii Cytotoxicity</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Mast cells participate in the host defense against parasites. Mast cells release leukotrienes (LTs), potent 5-lipoxygenase (LO) products of arachidonic acid well-known to be involved in the inflammatory process. After incubation with Toxoplasma gondii, mast cells were found to degranulate and release LTB4; this interaction damages the tachyzoites. This mast cell activity against the tachyzoites was inhibited by the 5-LO inhibitor A-63162 and the 5-LO-activating protein inhibitor MK-886 but not by the cyclooxygenase inhibitor indomethacin. Reactive oxygen species were not implicated in the mast cell-mediated toxoplasmacidal activity. The generation of LTs is important for mast cell secretion, and LTB4 released by mast cells and other inflammatory cells may be a key factor in the host defense against T. gondii.</description><subject>A-63162</subject><subject>Acetamides - pharmacology</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Arachidonate 5-Lipoxygenase - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion</subject><subject>Cells, Cultured</subject><subject>Concise Communications</subject><subject>Cytotoxicity</subject><subject>Eicosanoids</subject><subject>Enzyme Activation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Histamines</subject><subject>Immunobiology</subject><subject>Indoles - pharmacology</subject><subject>indomethacin</subject><subject>leukotriene B4</subject><subject>Leukotriene B4 - biosynthesis</subject><subject>Leukotrienes</subject><subject>Leukotrienes - biosynthesis</subject><subject>Leukotrienes - physiology</subject><subject>Lipoxygenase Inhibitors - pharmacology</subject><subject>Macrophages</subject><subject>Male</subject><subject>Mast cells</subject><subject>Mast Cells - parasitology</subject><subject>Mast Cells - physiology</subject><subject>Mast Cells - ultrastructure</subject><subject>Microscopy, Electron</subject><subject>MK-886</subject><subject>Organs and cells involved in the immune response</subject><subject>Parasite hosts</subject><subject>Parasites</subject><subject>Phenyl Ethers</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reactive oxygen species</subject><subject>Tachyzoites</subject><subject>Toxoplasma - drug effects</subject><subject>Toxoplasma - physiology</subject><subject>Toxoplasma - ultrastructure</subject><subject>Toxoplasma gondii</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLAzEYRYMoWqv-AyELcTeax0weSylqC1URqxU3Ic1kNDozqUkK7b93pKUuXeWDc7g3XABOMLrASLDLAnNB6Q7o4YLyjDFMd0EPIUIyLKQ8AIcxfiKEcsr4PtiXhaTd3QNPkw8LR83ch6RbY6Gv4NguvnwKzrY2QtfCOx0THNi6zu5s6XSyJZz4pZ_XOjYavvu2dA4OVsknv3TGpdUR2Kt0He3x5u2D55vryWCYjR9uR4OrcWaoZCmrBMLYED4rhZCzoszLGRWMFsIQQgTXgpGKM8SF1ISUWlQVtYLkwnDJtCE57YPzde48-O-FjUk1Lpruo7q1fhEVl0JiwdC_IuZF10vJn2iCjzHYSs2Da3RYKYzU78xqPXMnnm4SF7PGlltts2vHzzZcR6PrKnTjurjVCClQLuVfzGdMPmwxRV3Xb1EfZGvuYrLLLdfhSzFOeaGGr29qeE8fX6bTJ8XpD1ium1I</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Henderson, William R.</creator><creator>Chi, Emil Y.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19980501</creationdate><title>The Importance of Leukotrienes in Mast Cell-Mediated Toxoplasma gondii Cytotoxicity</title><author>Henderson, William R. ; Chi, Emil Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-f8011c27bd889b5d4db386358c22287a862f760789a22da8ff3e8248c796ac243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>A-63162</topic><topic>Acetamides - pharmacology</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Arachidonate 5-Lipoxygenase - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion</topic><topic>Cells, Cultured</topic><topic>Concise Communications</topic><topic>Cytotoxicity</topic><topic>Eicosanoids</topic><topic>Enzyme Activation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Histamines</topic><topic>Immunobiology</topic><topic>Indoles - pharmacology</topic><topic>indomethacin</topic><topic>leukotriene B4</topic><topic>Leukotriene B4 - biosynthesis</topic><topic>Leukotrienes</topic><topic>Leukotrienes - biosynthesis</topic><topic>Leukotrienes - physiology</topic><topic>Lipoxygenase Inhibitors - pharmacology</topic><topic>Macrophages</topic><topic>Male</topic><topic>Mast cells</topic><topic>Mast Cells - parasitology</topic><topic>Mast Cells - physiology</topic><topic>Mast Cells - ultrastructure</topic><topic>Microscopy, Electron</topic><topic>MK-886</topic><topic>Organs and cells involved in the immune response</topic><topic>Parasite hosts</topic><topic>Parasites</topic><topic>Phenyl Ethers</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reactive oxygen species</topic><topic>Tachyzoites</topic><topic>Toxoplasma - drug effects</topic><topic>Toxoplasma - physiology</topic><topic>Toxoplasma - ultrastructure</topic><topic>Toxoplasma gondii</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henderson, William R.</creatorcontrib><creatorcontrib>Chi, Emil Y.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henderson, William R.</au><au>Chi, Emil Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Importance of Leukotrienes in Mast Cell-Mediated Toxoplasma gondii Cytotoxicity</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>177</volume><issue>5</issue><spage>1437</spage><epage>1443</epage><pages>1437-1443</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Mast cells participate in the host defense against parasites. Mast cells release leukotrienes (LTs), potent 5-lipoxygenase (LO) products of arachidonic acid well-known to be involved in the inflammatory process. After incubation with Toxoplasma gondii, mast cells were found to degranulate and release LTB4; this interaction damages the tachyzoites. This mast cell activity against the tachyzoites was inhibited by the 5-LO inhibitor A-63162 and the 5-LO-activating protein inhibitor MK-886 but not by the cyclooxygenase inhibitor indomethacin. Reactive oxygen species were not implicated in the mast cell-mediated toxoplasmacidal activity. The generation of LTs is important for mast cell secretion, and LTB4 released by mast cells and other inflammatory cells may be a key factor in the host defense against T. gondii.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>9593043</pmid><doi>10.1086/517833</doi><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1998-05, Vol.177 (5), p.1437-1443 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online |
| subjects | A-63162 Acetamides - pharmacology Analysis of the immune response. Humoral and cellular immunity Animals Arachidonate 5-Lipoxygenase - metabolism Biological and medical sciences Cell Adhesion Cells, Cultured Concise Communications Cytotoxicity Eicosanoids Enzyme Activation Fundamental and applied biological sciences. Psychology Fundamental immunology Histamines Immunobiology Indoles - pharmacology indomethacin leukotriene B4 Leukotriene B4 - biosynthesis Leukotrienes Leukotrienes - biosynthesis Leukotrienes - physiology Lipoxygenase Inhibitors - pharmacology Macrophages Male Mast cells Mast Cells - parasitology Mast Cells - physiology Mast Cells - ultrastructure Microscopy, Electron MK-886 Organs and cells involved in the immune response Parasite hosts Parasites Phenyl Ethers Rats Rats, Sprague-Dawley Reactive oxygen species Tachyzoites Toxoplasma - drug effects Toxoplasma - physiology Toxoplasma - ultrastructure Toxoplasma gondii |
| title | The Importance of Leukotrienes in Mast Cell-Mediated Toxoplasma gondii Cytotoxicity |
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