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High-affinity platelet [ 3H]LSD binding is decreased in panic disorder

Platelet [ 3H]LSD binding was measured in 15 patients with panic attacks and 15 control. The mean (±SD) B max values of the patients (14.1 ±6.3 fmol/mg protein) and of the controls (18.5 ±4.7 fmol/mg protein) were significantly different ( P < 0.05, Mann-Whitney U-test). Mean (±SD) values of K d...

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Bibliographic Details
Published in:Journal of affective disorders 1990-06, Vol.19 (2), p.119-123
Main Authors: Norman, Trevor R., Judd, Fiona K., Staikos, Voula, Burrows, Graham D., McIntyre, Iain M.
Format: Article
Language:English
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Summary:Platelet [ 3H]LSD binding was measured in 15 patients with panic attacks and 15 control. The mean (±SD) B max values of the patients (14.1 ±6.3 fmol/mg protein) and of the controls (18.5 ±4.7 fmol/mg protein) were significantly different ( P < 0.05, Mann-Whitney U-test). Mean (±SD) values of K d for the patients (0.55 ± 0.34 nM) and for the controls (0.51 ± 0.12 nM) were not significantly different ( P > 0.1, Mann-Whitney U-test). The results are discussed in terms of a serotonergic hypothesis of the aetiology of panic disorders.
ISSN:0165-0327
1573-2517
DOI:10.1016/0165-0327(90)90016-2