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High-affinity platelet [ 3H]LSD binding is decreased in panic disorder
Platelet [ 3H]LSD binding was measured in 15 patients with panic attacks and 15 control. The mean (±SD) B max values of the patients (14.1 ±6.3 fmol/mg protein) and of the controls (18.5 ±4.7 fmol/mg protein) were significantly different ( P < 0.05, Mann-Whitney U-test). Mean (±SD) values of K d...
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Published in: | Journal of affective disorders 1990-06, Vol.19 (2), p.119-123 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Platelet [
3H]LSD binding was measured in 15 patients with panic attacks and 15 control. The mean (±SD)
B
max values of the patients (14.1 ±6.3 fmol/mg protein) and of the controls (18.5 ±4.7 fmol/mg protein) were significantly different (
P < 0.05, Mann-Whitney
U-test). Mean (±SD) values of
K
d for the patients (0.55 ± 0.34 nM) and for the controls (0.51 ± 0.12 nM) were not significantly different (
P > 0.1, Mann-Whitney
U-test). The results are discussed in terms of a serotonergic hypothesis of the aetiology of panic disorders. |
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ISSN: | 0165-0327 1573-2517 |
DOI: | 10.1016/0165-0327(90)90016-2 |