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High-affinity platelet [ 3H]LSD binding is decreased in panic disorder
Platelet [ 3H]LSD binding was measured in 15 patients with panic attacks and 15 control. The mean (±SD) B max values of the patients (14.1 ±6.3 fmol/mg protein) and of the controls (18.5 ±4.7 fmol/mg protein) were significantly different ( P < 0.05, Mann-Whitney U-test). Mean (±SD) values of K d...
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| Published in: | Journal of affective disorders 1990-06, Vol.19 (2), p.119-123 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c387t-fbe8c17754059732cb3a5098b57431aed61bc8041adc94195f847ceb3284937c3 |
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| cites | cdi_FETCH-LOGICAL-c387t-fbe8c17754059732cb3a5098b57431aed61bc8041adc94195f847ceb3284937c3 |
| container_end_page | 123 |
| container_issue | 2 |
| container_start_page | 119 |
| container_title | Journal of affective disorders |
| container_volume | 19 |
| creator | Norman, Trevor R. Judd, Fiona K. Staikos, Voula Burrows, Graham D. McIntyre, Iain M. |
| description | Platelet [
3H]LSD binding was measured in 15 patients with panic attacks and 15 control. The mean (±SD)
B
max values of the patients (14.1 ±6.3 fmol/mg protein) and of the controls (18.5 ±4.7 fmol/mg protein) were significantly different (
P < 0.05, Mann-Whitney
U-test). Mean (±SD) values of
K
d for the patients (0.55 ± 0.34 nM) and for the controls (0.51 ± 0.12 nM) were not significantly different (
P > 0.1, Mann-Whitney
U-test). The results are discussed in terms of a serotonergic hypothesis of the aetiology of panic disorders. |
| doi_str_mv | 10.1016/0165-0327(90)90016-2 |
| format | article |
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3H]LSD binding was measured in 15 patients with panic attacks and 15 control. The mean (±SD)
B
max values of the patients (14.1 ±6.3 fmol/mg protein) and of the controls (18.5 ±4.7 fmol/mg protein) were significantly different (
P < 0.05, Mann-Whitney
U-test). Mean (±SD) values of
K
d for the patients (0.55 ± 0.34 nM) and for the controls (0.51 ± 0.12 nM) were not significantly different (
P > 0.1, Mann-Whitney
U-test). The results are discussed in terms of a serotonergic hypothesis of the aetiology of panic disorders.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/0165-0327(90)90016-2</identifier><identifier>PMID: 2142698</identifier><identifier>CODEN: JADID7</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>[ 3H]LSD binding ; Adult ; Agoraphobia - blood ; Agoraphobia - psychology ; Biological and medical sciences ; Blood Platelets - metabolism ; Fear - physiology ; Female ; Humans ; Lysergic Acid Diethylamide - pharmacokinetics ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Panic - physiology ; Panic disorder ; Personality Tests ; Platelet ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Receptors, Serotonin - metabolism ; Serotonin receptors ; Sex Factors ; Techniques and methods</subject><ispartof>Journal of affective disorders, 1990-06, Vol.19 (2), p.119-123</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-fbe8c17754059732cb3a5098b57431aed61bc8041adc94195f847ceb3284937c3</citedby><cites>FETCH-LOGICAL-c387t-fbe8c17754059732cb3a5098b57431aed61bc8041adc94195f847ceb3284937c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19329147$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2142698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Norman, Trevor R.</creatorcontrib><creatorcontrib>Judd, Fiona K.</creatorcontrib><creatorcontrib>Staikos, Voula</creatorcontrib><creatorcontrib>Burrows, Graham D.</creatorcontrib><creatorcontrib>McIntyre, Iain M.</creatorcontrib><title>High-affinity platelet [ 3H]LSD binding is decreased in panic disorder</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Platelet [
3H]LSD binding was measured in 15 patients with panic attacks and 15 control. The mean (±SD)
B
max values of the patients (14.1 ±6.3 fmol/mg protein) and of the controls (18.5 ±4.7 fmol/mg protein) were significantly different (
P < 0.05, Mann-Whitney
U-test). Mean (±SD) values of
K
d for the patients (0.55 ± 0.34 nM) and for the controls (0.51 ± 0.12 nM) were not significantly different (
P > 0.1, Mann-Whitney
U-test). The results are discussed in terms of a serotonergic hypothesis of the aetiology of panic disorders.</description><subject>[ 3H]LSD binding</subject><subject>Adult</subject><subject>Agoraphobia - blood</subject><subject>Agoraphobia - psychology</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - metabolism</subject><subject>Fear - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Lysergic Acid Diethylamide - pharmacokinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Panic - physiology</subject><subject>Panic disorder</subject><subject>Personality Tests</subject><subject>Platelet</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Receptors, Serotonin - metabolism</subject><subject>Serotonin receptors</subject><subject>Sex Factors</subject><subject>Techniques and methods</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMotVb_gUIuih5W87WbzUWQaq1Q8KCeREI2ma2R7W5NtkL_vVu76M3DMAzzzMvwIHRMySUlNLvqKk0IZ_JckQtFujFhO2hIU8kTllK5i4a_yD46iPGDEJIpSQZowKhgmcqHaDL18_fElKWvfbvGy8q0UEGLXzGfvs2ebnHha-frOfYRO7ABTASHfY2XpvYWOx-b4CAcor3SVBGO-j5CL5O75_E0mT3eP4xvZonluWyTsoDcUilTQVIlObMFNylReZFKwakBl9HC5kRQ46wSVKVlLqSFgrNcKC4tH6Gzbe4yNJ8riK1e-GihqkwNzSpqqXLFM0Y7UGxBG5oYA5R6GfzChLWmRG_06Y0bvXGjFdE_-jTrzk76_FWxAPd71Pvq9qf93kRrqjKY2vr4l604U1TIjrvectDJ-PIQdLQeagvOB7Ctdo3__5Fvyq6JUw</recordid><startdate>19900601</startdate><enddate>19900601</enddate><creator>Norman, Trevor R.</creator><creator>Judd, Fiona K.</creator><creator>Staikos, Voula</creator><creator>Burrows, Graham D.</creator><creator>McIntyre, Iain M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900601</creationdate><title>High-affinity platelet [ 3H]LSD binding is decreased in panic disorder</title><author>Norman, Trevor R. ; Judd, Fiona K. ; Staikos, Voula ; Burrows, Graham D. ; McIntyre, Iain M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-fbe8c17754059732cb3a5098b57431aed61bc8041adc94195f847ceb3284937c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>[ 3H]LSD binding</topic><topic>Adult</topic><topic>Agoraphobia - blood</topic><topic>Agoraphobia - psychology</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - metabolism</topic><topic>Fear - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Lysergic Acid Diethylamide - pharmacokinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Panic - physiology</topic><topic>Panic disorder</topic><topic>Personality Tests</topic><topic>Platelet</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Receptors, Serotonin - metabolism</topic><topic>Serotonin receptors</topic><topic>Sex Factors</topic><topic>Techniques and methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norman, Trevor R.</creatorcontrib><creatorcontrib>Judd, Fiona K.</creatorcontrib><creatorcontrib>Staikos, Voula</creatorcontrib><creatorcontrib>Burrows, Graham D.</creatorcontrib><creatorcontrib>McIntyre, Iain M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norman, Trevor R.</au><au>Judd, Fiona K.</au><au>Staikos, Voula</au><au>Burrows, Graham D.</au><au>McIntyre, Iain M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-affinity platelet [ 3H]LSD binding is decreased in panic disorder</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>1990-06-01</date><risdate>1990</risdate><volume>19</volume><issue>2</issue><spage>119</spage><epage>123</epage><pages>119-123</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><coden>JADID7</coden><abstract>Platelet [
3H]LSD binding was measured in 15 patients with panic attacks and 15 control. The mean (±SD)
B
max values of the patients (14.1 ±6.3 fmol/mg protein) and of the controls (18.5 ±4.7 fmol/mg protein) were significantly different (
P < 0.05, Mann-Whitney
U-test). Mean (±SD) values of
K
d for the patients (0.55 ± 0.34 nM) and for the controls (0.51 ± 0.12 nM) were not significantly different (
P > 0.1, Mann-Whitney
U-test). The results are discussed in terms of a serotonergic hypothesis of the aetiology of panic disorders.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2142698</pmid><doi>10.1016/0165-0327(90)90016-2</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-0327 |
| ispartof | Journal of affective disorders, 1990-06, Vol.19 (2), p.119-123 |
| issn | 0165-0327 1573-2517 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79893621 |
| source | ScienceDirect: Psychology Backfile |
| subjects | [ 3H]LSD binding Adult Agoraphobia - blood Agoraphobia - psychology Biological and medical sciences Blood Platelets - metabolism Fear - physiology Female Humans Lysergic Acid Diethylamide - pharmacokinetics Male Medical sciences Middle Aged Miscellaneous Panic - physiology Panic disorder Personality Tests Platelet Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Serotonin - metabolism Serotonin receptors Sex Factors Techniques and methods |
| title | High-affinity platelet [ 3H]LSD binding is decreased in panic disorder |
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