An alternatively spliced form of the human CD94 gene

Human CD94 is one of the lectin-type natural killer (NK) receptors which are type II transmembrane proteins expressed on NK cells and subsets of T cells that possess a C-type lectin domain. CD94 recognizes HLA class I molecules on target cells by heterodimerization with NKG2-A or -C, other lectin-ty...

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Bibliographic Details
Published in:Immunogenetics (New York) 1998-06, Vol.48 (1), p.87-88
Main Authors: Furukawa, H, Yabe, T, Watanabe, K, Miyamoto, R, Akaza, T, Tadokoro, K, Tohma, S, Inoue, T, Yamamoto, K, Juji, T
Format: Article
Language:English
Subjects:
Alternative Splicing
Antigens, CD - genetics
Exons
Humans
Lectins, C-Type
Membrane Glycoproteins - genetics
Molecular Sequence Data
NK Cell Lectin-Like Receptor Subfamily D
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Summary:Human CD94 is one of the lectin-type natural killer (NK) receptors which are type II transmembrane proteins expressed on NK cells and subsets of T cells that possess a C-type lectin domain. CD94 recognizes HLA class I molecules on target cells by heterodimerization with NKG2-A or -C, other lectin-type NK receptors (Lazetic et al. 1996), and inhibits or activates the NK cytotoxicity. cDNA variants of several NK receptors have been produced by alternative splicing. We investigated an alternatively spliced cDNA variant of CD94 using reverse transcription-polymerase chain reaction (PCR) methods.
ISSN:0093-7711
1432-1211
DOI:10.1007/s002510050407