Sexual Dimorphism, Brain Morphology, and Schizophrenia

The study of sexual dimorphism in brain morphology may help delineate subtypes of schizophrenia based, in part, on sex; yield insight into the relationship between brain structure and behavior; and provide a neurodevelopmental context for studying the ontogenesis of schizophrenia. Preliminary findin...

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Bibliographic Details
Published in:Schizophrenia bulletin 1990, Vol.16 (2), p.195-203
Main Authors: Lewine, Richard R. J., Gulley, Lawrence R., Risch, S. Craig, Jewart, Rita, Houpt, Jeffrey L.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Bipolar Disorder - pathology
Brain
Brain - pathology
Corpus Callosum - pathology
Depressive Disorder - pathology
Dominance, Cerebral - physiology
Female
Human
Human Sex Differences
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Morphology
Neurocognitive Disorders - pathology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - pathology
Schizophrenic Psychology
Sex Characteristics
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Summary:The study of sexual dimorphism in brain morphology may help delineate subtypes of schizophrenia based, in part, on sex; yield insight into the relationship between brain structure and behavior; and provide a neurodevelopmental context for studying the ontogenesis of schizophrenia. Preliminary findings from an ongoing study of sex differences in brain morphology and neuropsychological performance in schizophrenia suggest that schizophrenic males are characterized by multiple morphological deviations; this may represent an extreme form of normal sexual dimorphism in brain morphology. The role of brain morphology deviation in the ontogenesis of schizophrenia is discussed.
ISSN:0586-7614
1745-1701
DOI:10.1093/schbul/16.2.195