Rod photoresponses in 6-week and 4-month-old human infants

Rod-only electroretinograms (ERGS) were recorded from 6-week and 4-month-old normal human infants. The leading edge of the rod a-wave was fitted with a model of the activation phase of phototransduction to provide estimates of S (a sensitivity parameter) and Rm P3 (the maximum saturated photorecepto...

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Bibliographic Details
Published in:Vision research (Oxford) 1998-03, Vol.38 (5), p.627-635
Main Authors: Nusinowitz, S., Birch, D.G., Birch, E.E.
Format: Article
Language:English
Subjects:
Aging
Biological and medical sciences
Dark Adaptation
Electroretinography
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
Humans
Infant
Infants
Light
Photoresponses
Retinal Rod Photoreceptor Cells - physiology
Rods
Time Factors
Vertebrates: nervous system and sense organs
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Summary:Rod-only electroretinograms (ERGS) were recorded from 6-week and 4-month-old normal human infants. The leading edge of the rod a-wave was fitted with a model of the activation phase of phototransduction to provide estimates of S (a sensitivity parameter) and Rm P3 (the maximum saturated photoreceptor response) at each of the investigated ages. Both S and Rm P3 increased over the first postnatal months but followed different developmental time courses with S approaching adult-like values sooner than Rm P3. The changes in S and Rm P3 can be interpreted within the context of a model incorporating the combined effects of increased levels of rhodopsin and the changing structure of the rod outer segment during development.
ISSN:0042-6989
1878-5646
DOI:10.1016/S0042-6989(97)00286-1