Hyaluronic acid plus heparin for improved efficacy in prevention of adhesion formation in rat uterine horn model

Objective: To determine the effectiveness of hyaluronic acid (HA) and heparin [unfractioned heparin (UH) or low molecular weight heparin (LMWH)] combination in reducing adhesion formation in a rat uterine horn model. Study Design: Prospective, randomized, comparative study in a rat model was done in...

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Published in:European journal of obstetrics & gynecology and reproductive biology 1998-05, Vol.78 (1), p.109-112
Main Authors: Başbuğ, Mustafa, Aygen, Ercan, Tayyar, Mehmet, Kaya, Erdal, Narin, Figen, Öktem, Özgür
Format: Article
Language:English
Subjects:
Adhesion formation
Adhesion prevention
Animals
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Drug Therapy, Combination
Female
Heparin
Heparin - administration & dosage
Heparin - therapeutic use
Heparin, Low-Molecular-Weight - administration & dosage
Heparin, Low-Molecular-Weight - therapeutic use
Hyaluronic acid
Hyaluronic Acid - administration & dosage
Hyaluronic Acid - therapeutic use
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Wistar
Tissue Adhesions - prevention & control
Uterine Diseases - prevention & control
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Summary:Objective: To determine the effectiveness of hyaluronic acid (HA) and heparin [unfractioned heparin (UH) or low molecular weight heparin (LMWH)] combination in reducing adhesion formation in a rat uterine horn model. Study Design: Prospective, randomized, comparative study in a rat model was done in Surgical Research Laboratory, Erciyes University. A standard lesion was created by unipolar electrocautery in 120 uterine horns of total 60 female Wistar-Albino rats. Animals were then randomly assigned into four groups, each consisting of 15 animals: (1) control, no adjuvant given; (2) HA, 1 ml of 0.4% solution given onto each horn preoperatively; (3) HA, 1 ml of 0.4% solution given preoperatively plus 1 ml of UH given postoperatively; (4) HA, 1 ml of 0.4% solution given before injury plus 1 ml of LMWH given after injury. A second-look laparotomy was performed two weeks after surgery. The number of horns with adhesion was determined and a scoring system applied. Result(s): The number of horns without adhesion formation was significantly higher in HA plus UH ( P
ISSN:0301-2115
1872-7654
DOI:10.1016/S0301-2115(98)00019-0