Inhibition of β-glucuronidase in Human Urine by Ascorbic Acid

The effects of oral supplementation of ascorbic acid (1500 mg d-1) on urinary β-glucuronidase (β-G) activity was assessed in a double-blind crossover study design over a 3-week period. The subjects on ascorbic acid treatment displayed a statistically significant (P < 0.05) decrease in β-G with an...

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Bibliographic Details
Published in:Human & experimental toxicology 1990-05, Vol.9 (3), p.165-170
Main Authors: Young, J.C., Kenyon, E.M., Calabrese, E.J.
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Ascorbic Acid - pharmacology
Ascorbic Acid - urine
Double-Blind Method
Glucuronidase - antagonists & inhibitors
Glucuronidase - urine
Humans
Hydrogen-Ion Concentration
Male
Pilot Projects
Random Allocation
Time Factors
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Summary:The effects of oral supplementation of ascorbic acid (1500 mg d-1) on urinary β-glucuronidase (β-G) activity was assessed in a double-blind crossover study design over a 3-week period. The subjects on ascorbic acid treatment displayed a statistically significant (P < 0.05) decrease in β-G with an approximate decrease of 25%.
ISSN:0960-3271
1477-0903
DOI:10.1177/096032719000900308