Effects of esmolol on haemodynamic response to CO2 pneumoperitoneum for laparoscopic surgery

Background: Carbon dioxide (CO2) pneumoperitoneum for laparoscopic surgery increases arterial pressures, systemic vascular resistance and heart rate and decreases urine output. Methods: In this double‐blind randomized study esmolol, an ultrashort‐acting β1‐adrenoceptor antagonist was compared with p...

Full description

Saved in:
Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 1998-05, Vol.42 (5), p.510-517
Main Authors: Koivusalo, A.-M., Scheinin, M., Tikkanen, I., Yli-Suomu, T., Ristkari, S., Laakso, J., Lindgren, L.
Format: Article
Language:English
Subjects:
Acetylglucosaminidase - urine
Adrenergic beta-Agonists - administration & dosage
Adrenergic beta-Agonists - therapeutic use
Adult
Alfentanil - administration & dosage
Anesthetics, Inhalation - administration & dosage
Anesthetics, Intravenous - administration & dosage
Biological and medical sciences
Blood Pressure - drug effects
Carbon Dioxide
Cardiovascular system
Double-Blind Method
Esmolol
Female
Heart Rate - drug effects
hemodynamics
Hemodynamics - drug effects
Humans
Ischemia - prevention & control
Isoflurane - administration & dosage
Kidney - blood supply
Laparoscopy
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Pneumoperitoneum, Artificial
Propanolamines - administration & dosage
Propanolamines - therapeutic use
renal function
Renin - blood
Sodium Chloride
Urine
Vascular Resistance - drug effects
Vasodilator agents. Cerebral vasodilators
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Carbon dioxide (CO2) pneumoperitoneum for laparoscopic surgery increases arterial pressures, systemic vascular resistance and heart rate and decreases urine output. Methods: In this double‐blind randomized study esmolol, an ultrashort‐acting β1‐adrenoceptor antagonist was compared with physiological saline (control) in 28 patients undergoing laparoscopic surgery in standardized 1 MAC isoflurane anaesthesia. Alfentanil infusion was used to prevent the increase of mean arterial pressure more than 25% from baseline. Results: Esmolol effectively prevented the pressor response to induction and maintenance of CO2 pneumoperitoneum. Significantly (P
ISSN:0001-5172
1399-6576
DOI:10.1111/j.1399-6576.1998.tb05159.x