Human gene for physical performance

A specific genetic factor that strongly influences human physical performance has not so far been reported, but here we show that a polymorphism in the gene encoding angiotensin-converting enzyme does just that. An 'insertion' allele of the gene is associated with elite endurance performan...

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Bibliographic Details
Published in:Nature (London) 1998-05, Vol.393 (6682), p.221-222
Main Authors: Montgomery, H. E, Marshall, R, Hemingway, H, Myerson, S, Clarkson, P, Dollery, C, Hayward, M, Holliman, D. E, Jubb, M, World, M, Thomas, E. L, Brynes, A. E, Saeed, N, Barnard, M, Bell, J. D, Prasad, K, Rayson, M, Talmud, P. J, Humphries, S. E
Format: Article
Language:English
Subjects:
Adult
Alleles
Biochemistry
Enzymes
Gene Frequency
Genotype
Genotype & phenotype
Humanities and Social Sciences
Humans
Male
Males
Middle Aged
Military Personnel
Mountaineering
multidisciplinary
Muscle, Skeletal - physiology
Peptidyl-Dipeptidase A - genetics
Peptidyl-Dipeptidase A - physiology
Physical Endurance - genetics
Physical Endurance - physiology
Physical Fitness - physiology
Physical training
Polymorphism
Science
Science (multidisciplinary)
scientific-correspondence
University colleges
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Description
Summary:A specific genetic factor that strongly influences human physical performance has not so far been reported, but here we show that a polymorphism in the gene encoding angiotensin-converting enzyme does just that. An 'insertion' allele of the gene is associated with elite endurance performance among high-altitude mountaineers. Also, after physical training, repetitive weight-lifting is improved eleven-fold in individuals homozygous for the 'insertion' allele compared with those homozygous for the 'deletion' allele.
ISSN:0028-0836
1476-4687
DOI:10.1038/30374