Translocation (3;13)(q27;q14): A Nonrandom and Probably Secondary Structural Change in Non-Hodgkin Lymphomas

Three cases of (3;13)(q27;q14) translocation observed in different histological types of non-Hodgkin lymphomas (NHLs) are reported here. This new recurring translocation in NHL was secondary in at least two of the patients because it was associated with another specific change [i.e., t(8;14)(q24;q32...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1998-06, Vol.103 (2), p.140-143
Main Authors: Laı̈, Jean-Luc, Daudignon, Agnès, Kerckaert, Jean-Pierre, Galiègue-Zouitina, Sylvie, Detourmignies, Laurence, Morel, Pierre, Bauters, Francis, Fenaux, Pierre
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Burkitt Lymphoma - genetics
Chromosome Aberrations - genetics
Chromosome Disorders
Chromosomes, Human, Pair 13 - genetics
Chromosomes, Human, Pair 3 - genetics
Female
Gene Rearrangement - genetics
Hematologic and hematopoietic diseases
Humans
Karyotyping
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Follicular - genetics
Lymphoma, Large B-Cell, Diffuse - genetics
Lymphoma, Non-Hodgkin - genetics
Medical sciences
Translocation, Genetic - genetics
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Summary:Three cases of (3;13)(q27;q14) translocation observed in different histological types of non-Hodgkin lymphomas (NHLs) are reported here. This new recurring translocation in NHL was secondary in at least two of the patients because it was associated with another specific change [i.e., t(8;14)(q24;q32) in Burkitt lymphoma and t(14;18)(q32;q21) in typical follicular lymphoma]. In two of the cases for which molecular analysis was performed, a rearrangement of the LAZ-3/BCL-6 gene was found.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(97)00391-9