Disseminated Fusarium solani infection with endocarditis in a lung transplant recipient

Eleven days after double lung transplantation for cystic fibrosis, an 18‐year‐old patient developed a disseminated Fusarium solani infection with tricuspid valve endocarditis. This infection occurred under fluconazole and immunosuppressive therapy with cyclosporin, prednisone and azathioprine, with...

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Bibliographic Details
Published in:Mycoses 1998-01, Vol.41 (1‐2), p.59-61
Main Authors: Guinvarc'h, A., Guilbert, L., Marmorat‐Khuong, A., Lavarde, Véronique, Chevalier, P., Amrein, C., Guillemain, R., Berrebi, A.
Format: Article
Language:English
Subjects:
Adolescent
Amphotericin B - therapeutic use
Antifungal Agents - therapeutic use
Biological and medical sciences
Cystic Fibrosis - surgery
disseminated fusariomycosis
disseminierte Fusariomykose
endocarditis
Endocarditis - microbiology
Endokarditis
Female
Fungemia - drug therapy
Fungemia - microbiology
Fusarium - drug effects
Fusarium - isolation & purification
Fusarium solani
Human mycoses
Humans
Immunocompromised Host
Infectious diseases
liposomal amphotericin B
liposomales Amphotericin B
Liposomes
lung transplantation
Lung Transplantation - adverse effects
Lungeniransplantation
Medical sciences
Miscellaneous mycoses
Mycoses
Mycoses - drug therapy
Mycoses - microbiology
Opportunistic Infections - drug therapy
Opportunistic Infections - microbiology
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Summary:Eleven days after double lung transplantation for cystic fibrosis, an 18‐year‐old patient developed a disseminated Fusarium solani infection with tricuspid valve endocarditis. This infection occurred under fluconazole and immunosuppressive therapy with cyclosporin, prednisone and azathioprine, with a normal leucocyte count. Liposomal amphotericin B allowed blood culture negativation. The patient died from a bacterial septic shock. Zusammenfassung. Elf Tage nach einer doppelten Lungentransplantation entwickelte eine 18‐jährige an Mukoviszidose erkrankte Patientin eine postoperative disseminierte Infektion mit einer Begleitendokarditis der Tricuspidalklappe. Als verantwortlicher Keim konnte Fusarium solani identifiziert werden. Die Infektion trat unter Fluconazol und einer immunosuppressiven Therapie mit Cyclosporin, Prednison und Azathioprin auf. Die Leukozyten blieben in der Norm. Unter Amphothericin B in liposomaler Form wurden die zuerst positiven Blutkulturen negativ. Die Patientin verstarb an den Folgen eines septischen Schocks bakterieller Genese.
ISSN:0933-7407
1439-0507
DOI:10.1111/j.1439-0507.1998.tb00378.x