PHARMACOKINETICS OF I.M. GLYCOPYRRONIUM

A sensitive radioreceptor assay was used to determine the pharmacokinetics of glyco-pyrronium following a single i.m. injection of 8 ug kg−1 in nine surgical patients. Rapid absorption was found, with a mean peak plasma concentration after 16.1 min and mean elimination half-life of 75.4 min. Almost...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1990-06, Vol.64 (6), p.667-669
Main Authors: ALI-MELKKILÄ, T.M., KAILA, T., KANTO, J., IISALO, E.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Pressure - drug effects
Cholinergic system
Female
Glycopyrrolate - administration & dosage
Glycopyrrolate - blood
Glycopyrrolate - pharmacokinetics
Half-Life
Heart Rate - drug effects
Humans
Injections, Intramuscular
Medical sciences
Middle Aged
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
Pyrrolidines - pharmacokinetics
Salivation - drug effects
Time Factors
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Summary:A sensitive radioreceptor assay was used to determine the pharmacokinetics of glyco-pyrronium following a single i.m. injection of 8 ug kg−1 in nine surgical patients. Rapid absorption was found, with a mean peak plasma concentration after 16.1 min and mean elimination half-life of 75.4 min. Almost half (49.3%) of the drug was excreted in pharmacologically active form in the urine within 3 h. A significant increase in heart rate (P < 0.05) occurred in 15 min, lasting up to 60 min, and an antisialagogue effect in 10 min, lasting up to 8 h (P < 0.05). There was no measurable glycopyrronium in lumbar cerebrospinal fluid samples (n = 9) taken 40 min after administration of drug.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/64.6.667