Production of desferrioxamine E and new analogues by directed fermentation and feeding fermentation

Streptomyces olivaceus TU 2718 produces the siderophore desferrioxamine E. Production depends on L-lysine and iron concentrations in the medium. With optimized conditions the yield of desferrioxamine E could be increased to 12 g/l in feeding fermentations. Supplementation of the basic production med...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 1990-02, Vol.32 (5), p.505-510
Main Authors: Meiwes, J, Fiedler, H.P, Zahner, H, Konetschny-Rapp, S, Jung, G
Format: Article
Language:English
Subjects:
Bacteriological Techniques
Biological and medical sciences
Biotechnology
Chromatography, High Pressure Liquid
Culture Media
Deferoxamine - isolation & purification
Deferoxamine - metabolism
derivatives
desferrioxamine E
Fermentation
Fundamental and applied biological sciences. Psychology
Hydrogen-Ion Concentration
iron
Iron - metabolism
Lysine - metabolism
macrophages
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
production
siderophores
Streptomyces
Streptomyces - growth & development
Streptomyces - metabolism
Sucrose - metabolism
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Summary:Streptomyces olivaceus TU 2718 produces the siderophore desferrioxamine E. Production depends on L-lysine and iron concentrations in the medium. With optimized conditions the yield of desferrioxamine E could be increased to 12 g/l in feeding fermentations. Supplementation of the basic production medium with natural and synthetic precursors of desferrioxamine E led to the production of twelve new analogues of desferrioxamine E.
ISSN:0175-7598
1432-0614
DOI:10.1007/BF00173718