Entry of Alphaherpesviruses Mediated by Poliovirus Receptor-Related Protein 1 and Poliovirus Receptor

A human member of the immunoglobulin superfamily was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HSV) 1 and 2, porcine pseudorabies virus (PRV), and bovine herpesvirus 1 (BHV-1). This membrane glycoprotein is poliovirus receptor-related protein 1 (Prr1), d...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1998-06, Vol.280 (5369), p.1618-1620
Main Authors: Geraghty, Robert J., Krummenacher, Claude, Cohen, Gary H., Eisenberg, Roselyn J., Spear, Patricia G.
Format: Article
Language:English
Subjects:
Alphaherpesvirinae - physiology
Anatomy
Animals
Base Sequence
Biological and medical sciences
Cell Adhesion Molecules - genetics
Cell Adhesion Molecules - physiology
Cell lines
Cells, Cultured
CHO Cells
Complementary DNA
Cricetinae
Epithelial Cells - virology
Fundamental and applied biological sciences. Psychology
Gene Expression
HeLa cells
Herpes viruses
Herpesvirus 1, Bovine - physiology
Herpesvirus 1, Human - physiology
Herpesvirus 1, Suid - physiology
Herpesvirus 2, Human - physiology
Human herpesvirus 1
Human herpesvirus 2
Humans
Infections
Membrane Proteins
Microbiology
Molecular Sequence Data
Nectins
Neurons
Neurons - virology
Polymerase Chain Reaction
Proteins
Receptors, Virus
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
T lymphocytes
Transfection
Tumor Cells, Cultured
Viral Envelope Proteins - metabolism
Virology
Viruses
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Description
Summary:A human member of the immunoglobulin superfamily was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HSV) 1 and 2, porcine pseudorabies virus (PRV), and bovine herpesvirus 1 (BHV-1). This membrane glycoprotein is poliovirus receptor-related protein 1 (Prr1), designated here as HveC. Incubation of HSV-1 with a secreted form of HveC inhibited subsequent infection of a variety of cell lines, suggesting that HveC interacts directly with the virus. Poliovirus receptor (Pvr) itself mediated entry of PRV and BHV-1 but not of the HSV strains tested. HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.280.5369.1618