Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese

We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the cont...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the neurological sciences 1998-05, Vol.157 (2), p.158-161
Main Authors: Hu, Chaur-Jong, Sung, Shing-Ming, Liu, Hsing-Cheng, Chang, Jan-Gowth
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - blood
Alzheimer Disease - genetics
Alzheimer's disease
Apolipoprotein E
Apolipoproteins E - blood
Apolipoproteins E - genetics
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Chinese
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Female
Genetics
Genotype
Humans
Introns
Male
Medical sciences
Membrane Proteins - blood
Membrane Proteins - genetics
Neurology
Polymerase Chain Reaction
Polymorphism, Genetic
Presenilin-1
Taiwan - epidemiology
Tropical medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P
ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(98)00052-5