Serum gelsolin and rhabdomyolysis

We measured the serum gelsolin, actin-modulating protein, levels in five patients after rhabdomyolysis. We observed a tendency of serum gelsolin (83 kDa) to increase during the study period of 11 days. No intracellular gelsolin (80 kDa) was found in the serum, although it is abundant in muscle, and...

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Bibliographic Details
Published in:Journal of the neurological sciences 1998-05, Vol.157 (2), p.187-190
Main Authors: Löfberg, Mervi, Paunio, Tiina, Tähtelä, Riitta, Kiuru, Sari, Somer, Hannu
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Biological and medical sciences
Blotting, Western
Diseases of striated muscles. Neuromuscular diseases
Female
Gelsolin
Gelsolin - blood
Gelsolin - metabolism
Humans
Intracellular Fluid - metabolism
Male
Medical sciences
Middle Aged
Muscle, Skeletal - metabolism
Neurology
Rhabdomyolysis
Rhabdomyolysis - blood
Rhabdomyolysis - pathology
Serum gelsolin
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Summary:We measured the serum gelsolin, actin-modulating protein, levels in five patients after rhabdomyolysis. We observed a tendency of serum gelsolin (83 kDa) to increase during the study period of 11 days. No intracellular gelsolin (80 kDa) was found in the serum, although it is abundant in muscle, and the destruction was severe as judged by other parameters. Serum gelsolin thus behaves differently in rhabdomyolysis than after acute tissue damage in other organs, such as liver necrosis and adult respiratory distress syndrome.
ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(98)00056-2