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Serum gelsolin and rhabdomyolysis

We measured the serum gelsolin, actin-modulating protein, levels in five patients after rhabdomyolysis. We observed a tendency of serum gelsolin (83 kDa) to increase during the study period of 11 days. No intracellular gelsolin (80 kDa) was found in the serum, although it is abundant in muscle, and...

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Published in:	Journal of the neurological sciences 1998-05, Vol.157 (2), p.187-190
Main Authors:	Löfberg, Mervi, Paunio, Tiina, Tähtelä, Riitta, Kiuru, Sari, Somer, Hannu
Format:	Article
Language:	English
Subjects:	Acute Disease Adult Biological and medical sciences Blotting, Western Diseases of striated muscles. Neuromuscular diseases Female Gelsolin Gelsolin - blood Gelsolin - metabolism Humans Intracellular Fluid - metabolism Male Medical sciences Middle Aged Muscle, Skeletal - metabolism Neurology Rhabdomyolysis Rhabdomyolysis - blood Rhabdomyolysis - pathology Serum gelsolin
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container_end_page	190
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container_title	Journal of the neurological sciences
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creator	Löfberg, Mervi Paunio, Tiina Tähtelä, Riitta Kiuru, Sari Somer, Hannu
description	We measured the serum gelsolin, actin-modulating protein, levels in five patients after rhabdomyolysis. We observed a tendency of serum gelsolin (83 kDa) to increase during the study period of 11 days. No intracellular gelsolin (80 kDa) was found in the serum, although it is abundant in muscle, and the destruction was severe as judged by other parameters. Serum gelsolin thus behaves differently in rhabdomyolysis than after acute tissue damage in other organs, such as liver necrosis and adult respiratory distress syndrome.
doi_str_mv	10.1016/S0022-510X(98)00056-2
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subjects	Acute Disease Adult Biological and medical sciences Blotting, Western Diseases of striated muscles. Neuromuscular diseases Female Gelsolin Gelsolin - blood Gelsolin - metabolism Humans Intracellular Fluid - metabolism Male Medical sciences Middle Aged Muscle, Skeletal - metabolism Neurology Rhabdomyolysis Rhabdomyolysis - blood Rhabdomyolysis - pathology Serum gelsolin
title	Serum gelsolin and rhabdomyolysis
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