A54145, A NEW LIPOPEPTIDE ANTIBIOTIC COMPLEX: MICROBIAL AND CHEMICAL MODIFICATION

A54145 is a complex of acidic lipopeptide antibiotics produced by Streptomyces fradiae NRRL 18158, NRRL 18159, and NRRL 18160. Each antibiotic factor consists of a peptide core bearing an N-terminal acyl substituent. N-Lys-tert-BOC-protected A54145 complex was deacylated by Actinoplanes utahensis; t...

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Bibliographic Details
Published in:Journal of antibiotics 1990/06/25, Vol.43(6), pp.601-606
Main Authors: FUKUDA, D. S., DEBONO, M., MOLLOY, R. M., MYNDERSE, J. S.
Format: Article
Language:English
Subjects:
Actinomycetales - metabolism
Acylation
Amino Acid Sequence
Anti-Bacterial Agents - metabolism
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Lipoproteins - metabolism
Microbiology
Molecular Sequence Data
Streptomyces fradiae
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Description
Summary:A54145 is a complex of acidic lipopeptide antibiotics produced by Streptomyces fradiae NRRL 18158, NRRL 18159, and NRRL 18160. Each antibiotic factor consists of a peptide core bearing an N-terminal acyl substituent. N-Lys-tert-BOC-protected A54145 complex was deacylated by Actinoplanes utahensis; three protected core peptides were isolated. A54145 antibiotic analogs were synthesized by acylation of the tryptophan N-terminus with 2, 4, 5-trichlorophenyl active esters, followed by deblocking with trifluoroacetic acid.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.43.601