Blood Coagulation in Hemophilia A and Hemophilia C

Tissue factor (TF)-induced coagulation was compared in contact pathway suppressed human blood from normal, factor VIII-deficient, and factor XI-deficient donors. The progress of the reaction was analyzed in quenched samples by immunoassay and immunoblotting for fibrinopeptide A (FPA), thrombin-antit...

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Bibliographic Details
Published in:Blood 1998-06, Vol.91 (12), p.4581-4592
Main Authors: Cawthern, Kevin M., van 't Veer, Cornelis, Lock, Jennifer B., DiLorenzo, Maria E., Branda, Richard F., Mann, Kenneth G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Blood Coagulation - drug effects
Factor XI Deficiency - blood
Hematologic and hematopoietic diseases
Hemophilia A - blood
Humans
Immunoblotting
Male
Medical sciences
Middle Aged
Platelet diseases and coagulopathies
Thromboplastin - pharmacology
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Summary:Tissue factor (TF)-induced coagulation was compared in contact pathway suppressed human blood from normal, factor VIII-deficient, and factor XI-deficient donors. The progress of the reaction was analyzed in quenched samples by immunoassay and immunoblotting for fibrinopeptide A (FPA), thrombin-antithrombin (TAT), factor V activation, and osteonectin. In hemophilia A blood (factor VIII:C
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V91.12.4581