Transcranial Doppler blood flow velocity versus 133Xe clearance cerebral blood flow during mild hypothermic cardiopulmonary bypass

Transcranial doppler (TCD) is used during cardiopulmonary bypass (CPB) to assess cerebral emboli and to estimate cerebral perfusion. We sought to compare TCD middle cerebral artery blood flow velocity (Vmca) to 133Xe clearance cerebral blood flow (CBF) measurements during mild hypothermic CPB thus d...

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Bibliographic Details
Published in:Journal of clinical monitoring and computing 1998-01, Vol.14 (1), p.35-39
Main Authors: Grocott, H P, Amory, D W, Lowry, E, Croughwell, N D, Newman, M F
Format: Article
Language:English
Subjects:
Analysis of Variance
Blood Flow Velocity - physiology
Cardiopulmonary Bypass
Cerebral Arteries - diagnostic imaging
Cerebrovascular Circulation - physiology
Coronary Artery Bypass
Female
Humans
Hypothermia, Induced - methods
Intracranial Embolism and Thrombosis - diagnostic imaging
Linear Models
Male
Middle Aged
Monitoring, Intraoperative
Radionuclide Imaging
Radiopharmaceuticals
Time Factors
Ultrasonography, Doppler, Transcranial
Xenon Radioisotopes
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Summary:Transcranial doppler (TCD) is used during cardiopulmonary bypass (CPB) to assess cerebral emboli and to estimate cerebral perfusion. We sought to compare TCD middle cerebral artery blood flow velocity (Vmca) to 133Xe clearance cerebral blood flow (CBF) measurements during mild hypothermic CPB thus determining its utility in cerebral perfusion assessment. Thirty-four patients undergoing mild hypothermic CPB (35 degrees C) were studied and had comparisons of Vmca and 133Xe CBF at three time intervals, 10, 30 and 60 min after the institution of CPB. Linear regression analysis was performed on data from each of the 3 intervals as well as for pooled data from all 3 periods. The correlation coefficients for the 3 time periods were, r = 0.32 (p = 0.12), r = 0.32 (p = 0.11), r = 0.48 (p = (0.02), respectively. The pooled data correlation had a coefficient of 0.34 (p = 0.003). These findings suggest that TCD Vmca is a relatively poor correlate of CBF during mild hypothermic CPB.
ISSN:1387-1307