Pre‐induction behaviour of children A review of placebo‐controlled trials of sedatives

Summary Placebo‐controlled trials of sedative premedication in children are reviewed in an attempt to determine which drugs have been shown to reduce the frequency with which children cry or appear apprehensive. Small samples and inappropriate statistical methods limit the value of many of the studi...

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Bibliographic Details
Published in:Anaesthesia 1990-06, Vol.45 (6), p.427-435
Main Authors: MORGAN‐HUGHES, J. O., BANGHAM, J. A.
Format: Article
Language:English
Subjects:
Anaesthesia
paediatric
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Child
Child Behavior - drug effects
Child, Preschool
Clinical Trials as Topic
Humans
Hypnotics and Sedatives - pharmacology
Infant
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Placebos
Preanesthetic Medication
Premedication
antisialagogues, benzodiazepines, barbiturates, phenothiazines, opioids
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Summary:Summary Placebo‐controlled trials of sedative premedication in children are reviewed in an attempt to determine which drugs have been shown to reduce the frequency with which children cry or appear apprehensive. Small samples and inappropriate statistical methods limit the value of many of the studies. Most of the drugs tested will, in sufficient dose, increase the proportion of children who are asleep. Only intramuscular opioid analgesics, either alone or in combination with other drugs, have been shown repeatedly to increase the frequency of calm behaviour in those who are awake. There is some evidence, however, that intramuscular placebo controls have a lower frequency of calm behaviour than oral placebo controls.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1990.tb14326.x