The effect of exercise on leptin concentration in healthy men and in type 1 diabetic patients

• Published in: Medicine and science in sports and exercise 1998-06, Vol.30 (6), p.805-810
• Main Authors: KOISTINEN, HEIKKI A, TUOMINEN, JUHA A, EBELING, PERTTI, HEIMAN, MARK L, STEPHENS, THOMAS W, KOIVISTO, VEIKKO A
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Circadian Rhythm; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Exercise - physiology; Fasting - physiology; Humans; Leptin; Male; Management. Various non-drug treatments. Langerhans islet grafts; Medical sciences; Proteins - analysis; Proteins - metabolism; Space life sciences; Time Factors
• ISSN: 0195-9131; 1530-0315
• DOI: 10.1097/00005768-199806000-00005

The effect of exercise on leptin concentration in healthy men and in type 1 diabetic patients. Med. Sci. Sports Exerc., Vol. 30, No. 6, pp. 805-810, 1998. PURPOSE:Leptin is a recently discovered hormone that appears as a regulator of energy balance. It is important to know whether leptin concentrations are changed under conditions of altered energy homeostasis. Consequently, we examined the effects of exercise with fasting and exercise with feeding on circulating leptin concentrations in healthy men and in type 1 diabetic patients with normal body weight and well controlled diabetes. METHODS:Leptin concentrations were determined with radioimmunoassay. RESULTS:During a 3-h cycle ergometer exercise with fasting, leptin decreased by 42% (P < 0.01) in nine healthy men and by 23% (P = 0.05) in eight male type 1 diabetic patients. Leptin fell equally by 12% (P < 0.03) both in nine healthy men and in eight male type 1 diabetic patients who were studied as a resting control group. The absolute fall in leptin in healthy men was similar in the exercise and resting control groups (0.8 ± 0.1 μg·L vs 0.8 ± 0.2 μg·L). However, due to lower leptin concentration before the exercise, the relative decrease (42%) was greater than during the resting control study (12%, P < 0.005). This difference was not seen in the diabetic patients. Fasting leptin concentration correlated positively with BMI (r = 0.75, P < 0.001) and fasting insulin (r = 0.71, P < 0.01) in healthy men as well as with insulin level (r = 0.54, p