Temporal correlation between adenosine outflow and synaptic potential inhibition in rat hippocampal slices during ischemia-like conditions

The temporal correlation between adenosine outflow and changes in field excitatory post synaptic potentials (fEPSP) occurring during ischemia-like conditions was investigated in rat hippocampal slices. Five-minute long ischemia-like conditions resulted in a 100% depression of fEPSP amplitude, follow...

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Bibliographic Details
Published in:Brain research 1998-06, Vol.794 (2), p.325-328
Main Authors: Latini, Serena, Bordoni, Francesca, Corradetti, Renato, Pepeu, Giancarlo, Pedata, Felicita
Format: Article
Language:English
Subjects:
Adenosine - metabolism
Adenosine outflow
Animals
Biological and medical sciences
Brain Ischemia - metabolism
Excitatory postsynaptic potential
Excitatory Postsynaptic Potentials
Hippocampal slice
Hippocampus - blood supply
Hippocampus - metabolism
In Vitro Techniques
Ischemia
Male
Medical sciences
Neurology
Rats
Rats, Wistar
Synaptic Transmission - physiology
Time Factors
Vascular diseases and vascular malformations of the nervous system
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Summary:The temporal correlation between adenosine outflow and changes in field excitatory post synaptic potentials (fEPSP) occurring during ischemia-like conditions was investigated in rat hippocampal slices. Five-minute long ischemia-like conditions resulted in a 100% depression of fEPSP amplitude, followed by a complete recovery after 6–7 min of reperfusion. By reducing the duration of the ischemic insult to 2 min, fEPSP was depressed by 50%. During both 5 and 2 min of ischemia-like conditions, a significant increase in adenosine outflow was detected. During reperfusion, when fEPSP amplitude recovered completely, the adenosine level in the extracellular fluid returned to basal values. The strict relationship between the increase in adenosine outflow and fEPSP inhibition supports the hypothesis that adenosine is largely responsible for the synaptic transmission depression during cerebral ischemia.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(98)00304-7