Lectin histochemistry of laryngeal squamous cell carcinomas

A panel of five biotinylated lectins was applied to study the presence and distribution of membrane carbohydrate residues in the normal laryngeal epithelium and in laryngeal squamous cell carcinomas (SCCs) of 86 patients with the avidin-biotin peroxidase complex technique. The lectin-binding pattern...

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Bibliographic Details
Published in:Otolaryngology-head and neck surgery 1998-06, Vol.118 (6), p.886-891
Main Authors: TSAMBAOS, DIONYSIOS, PASMATZI, EFI, MANOLOPOULOS, LEONIDAS, KAPRANOS, NIKIFOROS, GOUMAS, PANOS, ADAMOPOULOS, GEORGE
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Membrane
Cell Transformation, Neoplastic
Epithelium - metabolism
Humans
Immunoenzyme Techniques
Laryngeal Neoplasms - metabolism
Laryngeal Neoplasms - pathology
Larynx - cytology
Larynx - metabolism
Lectins - metabolism
Middle Aged
Neoplasm Staging
Protein Binding
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Summary:A panel of five biotinylated lectins was applied to study the presence and distribution of membrane carbohydrate residues in the normal laryngeal epithelium and in laryngeal squamous cell carcinomas (SCCs) of 86 patients with the avidin-biotin peroxidase complex technique. The lectin-binding pattern of well-differentiated SCCs was comparable to that of the spinous cells of the normal laryngeal epithelium. In the less differentiated SCCs, staining of the keratinocyte plasma membrane with lectins was either reduced or absent, indicating a decline in the glycosylation of cell surface glycoconjugates. The lectins applied here could be used in the rapid assessment of less-differentiated areas within a laryngeal SCC, but they cannot be regarded as reliable markers of laryngeal keratinocytes undergoing malignant transformation. (Otolaryngol Head Neck Surg 1998;118:886-91.)
ISSN:0194-5998
1097-6817
DOI:10.1016/S0194-5998(98)70292-X