Stress-Induced Enhancement of Cell-Mediated Immunity

We have demonstrated that acute stress induces a large-magnitude, rapid, and reversible redistribution of leukocytes from the blood to other compartments within the body. These changes in leukocyte distribution are mediated by adrenal stress hormones. Because the skin is one of the target organs of...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1998-05, Vol.840 (1), p.359-372
Main Author: DHABHAR, FIRDAUS S.
Format: Article
Language:English
Subjects:
Animals
Circadian Rhythm - physiology
Humans
Hypersensitivity, Delayed - physiopathology
Immunity, Cellular - physiology
Leukocytes - pathology
Skin - immunology
Stress, Physiological - immunology
Stress, Physiological - pathology
Stress, Physiological - physiopathology
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Summary:We have demonstrated that acute stress induces a large-magnitude, rapid, and reversible redistribution of leukocytes from the blood to other compartments within the body. These changes in leukocyte distribution are mediated by adrenal stress hormones. Because the skin is one of the target organs of a stress-induced redistribution of leukocyes, we hypothesized that such a leukocyte redistribution could be one of the factors by which acute stress may enhance cutaneous immune function. This hypothesis was tested by examining the effects of acute stress on cutaneous delayed-type hypersensitivity (DTH). DTH reactions are antigen-specific, cell-mediated immune responses that, depending on the antigen involved, mediate beneficial (resistance to viruses, bacteria, and fungi) or harmful (allergic dermatitis, autoimmunity) aspects of immune function. DTH was induced by challenging the pinnae of previously sensitized rats with 2,4-dinitro-1-fluorobenzene (DNFB). Experiments showed that acute stress administered immediately before the introduction of an antigenic challenge significantly enhances a cutaneous DTH response. In contrast, chronic stress suppresses cutaneous DTH. These results demonstrate a bidirectional relationship between stress and immune function, such that acute stress enhances, while chronic stress suppresses, an important class of immune responses in vivo. They also suggest that stress-induced alterations in lymphocyte redeployment within the body may play an important role in mediating these bidirectional effects of stress on cell-mediated immunity.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1998.tb09575.x