Cloning of the IGF-1 Receptor cDNA of Turbot (Scophthalmus maximus): Messenger Expression and Polyadenylation Status

The insulin-like growth factors (IGFs) play important roles in regulating growth and development in vertebrates. Most of their actions are mediated by the IGF type 1 receptor (IGF-1R) which is a tetrameric protein composed of two alpha and beta subunits linked by disulfide bonds. The alpha and beta...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1998-05, Vol.839 (1), p.513-514
Main Authors: ELIES, GISÈLE, GROIGNO, LAURENCE, WOLFF, JACQUES, BOEUF, GILLES, BOUJARD, DANIEL
Format: Article
Language:English
Subjects:
Animals
Cloning, Molecular
DNA, Complementary - genetics
Flatfishes - genetics
Flatfishes - metabolism
Marine
Receptor, IGF Type 1 - genetics
RNA, Messenger - biosynthesis
Scophthalmus maximus
Species Specificity
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Summary:The insulin-like growth factors (IGFs) play important roles in regulating growth and development in vertebrates. Most of their actions are mediated by the IGF type 1 receptor (IGF-1R) which is a tetrameric protein composed of two alpha and beta subunits linked by disulfide bonds. The alpha and beta subunits arise from the processing of a single-chain preproreceptor. The alpha subunits, which are entirely extracellular, contain the ligand binding sites, whereas the beta subunits span the membrane and exhibit a tyrosine kinase domain in their cytoplasmic region. Cloning and sequencing of the complete IGF-1R cDNA have so far been reported only in two mammals, human and rat. In submammals, two cDNAs corresponding to a portion of the alpha and beta subunits have been described in chicken, whereas in Xenopus the sequence of a cDNA encoding nearly the entire beta subunit has been reported.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1998.tb10854.x