Distribution of novel CGRP1 receptor and adrenomedullin receptor mRNAs in the rat central nervous system

Recent cloning studies have isolated receptors which confer specific responsiveness to calcitonin gene related peptide (CGRP) and the related peptide adrenomedullin. Using in situ hybridisation, we demonstrate the heterogenous distribution of the mRNAs of two proposed CGRP1 receptors (RDC-1 and calc...

Full description

Saved in:
Bibliographic Details
Published in:Brain research. Molecular brain research. 1998-06, Vol.57 (1), p.149-154
Main Authors: OLIVER, K. R, WAINWRIGHT, A, HEAVENS, R. P, HILL, R. G, SIRINATHSINGHJI, D. J. S
Format: Article
Language:English
Subjects:
Amygdala - chemistry
Animals
Biological and medical sciences
Brain Chemistry
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Fundamental and applied biological sciences. Psychology
GTP-Binding Proteins - genetics
In Situ Hybridization
Male
Membrane Proteins - genetics
Neostriatum - chemistry
Oligonucleotide Probes
Pia Mater - chemistry
Rats
Rats, Sprague-Dawley
Receptors, Adrenomedullin
Receptors, Calcitonin Gene-Related Peptide - genetics
Receptors, Peptide
RNA, Messenger - analysis
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent cloning studies have isolated receptors which confer specific responsiveness to calcitonin gene related peptide (CGRP) and the related peptide adrenomedullin. Using in situ hybridisation, we demonstrate the heterogenous distribution of the mRNAs of two proposed CGRP1 receptors (RDC-1 and calcitonin receptor-like receptor, CRLR) in the rat brain. Adrenomedullin receptor mRNA was weakly expressed, principally in the cerebellum. These findings may assist in the determination of the function of these largely uncharacterised receptors.
ISSN:0169-328X
1872-6941
DOI:10.1016/s0169-328x(98)00052-7