Immunisation with live attenuated Salmonella dublin expressing a sporozoite protein confers partial protection against Theileria parva

Cattle immunised with a recombinant form of p67, the major surface antigen of Theileria parva sporozoites, have been shown to be protected against parasite challenge. In an attempt to simplify the immunisation procedure live attenuated Salmonella strains expressing p67 have been constructed and used...

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Bibliographic Details
Published in:Vaccine 1998-05, Vol.16 (8), p.834-841
Main Authors: Heussler, V.T., Taracha, E.L.N., Musoke, A., Duchateau, L., McKeever, D.J.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Protozoan - biosynthesis
attenuated Salmonella
Bacterial Vaccines - immunology
Biological and medical sciences
Cattle
CD4-Positive T-Lymphocytes - immunology
Fundamental and applied biological sciences. Psychology
Immunity, Cellular
Protozoa
Protozoan Proteins - genetics
Protozoan Proteins - immunology
recombinant antigen
Recombinant Fusion Proteins - immunology
Salmonella - immunology
Species Specificity
Theileria parva
Theileria parva - growth & development
Theileria parva - immunology
Theileriasis - immunology
Theileriasis - prevention & control
Vaccination - veterinary
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, Attenuated - immunology
Vaccines, Synthetic - immunology
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Summary:Cattle immunised with a recombinant form of p67, the major surface antigen of Theileria parva sporozoites, have been shown to be protected against parasite challenge. In an attempt to simplify the immunisation procedure live attenuated Salmonella strains expressing p67 have been constructed and used to induce anti-p67 immune responses in cattle. All animals immunised with these strains developed strong antibody responses to p67. Specific T cell responses could be detected in the majority of immunised cattle. Challenge with T. parva sporozoites revealed a significant level of protection in immunised calves compared to naive control animals or animals inoculated with non-recombinant attenuated Salmonella.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(97)00263-6