Systemic immunization with urease protects mice against Helicobacter pylori infection

The ability of systemic immunization to induce protection against Helicobacter pylori infection has been evaluated in a mouse model. It was observed that if appropriate formulations and adjuvants were used such immunization elicited in outbred Swiss mice levels of protection similar or better than t...

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Bibliographic Details
Published in:Vaccine 1998-05, Vol.16 (8), p.850-856
Main Authors: Guy, Bruno, Hessler, Catherine, Fourage, Sophie, Haensler, Jean, Vialon-Lafay, Elisabeth, Rokbi, Bachra, Quentin Millet, Marie-José
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
Administration, Oral
AIDS/HIV
Animals
Bacterial Proteins - immunology
Bacterial Vaccines - administration & dosage
Bacterial Vaccines - immunology
Bacteriology
Biological and medical sciences
Feasibility Studies
Fundamental and applied biological sciences. Psychology
Gastritis - microbiology
Gastritis - prevention & control
Helicobacter Infections - prevention & control
Helicobacter pylori - immunology
Injections, Subcutaneous
Mice
Microbiology
Stomach - microbiology
Th1 Cells - drug effects
Th1 Cells - immunology
Th2 Cells - drug effects
Th2 Cells - immunology
Urease - immunology
Vaccination
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, Synthetic - administration & dosage
Vaccines, Synthetic - immunology
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Summary:The ability of systemic immunization to induce protection against Helicobacter pylori infection has been evaluated in a mouse model. It was observed that if appropriate formulations and adjuvants were used such immunization elicited in outbred Swiss mice levels of protection similar or better than those induced by the oral route in the presence of cholera toxin or Escherichia coli heat labile toxin. Recombinant urease mixed with adjuvants, which induced strong Th1 and Th2 responses elicited better protection than urease mixed with adjuvants which induced a predominant Th2 type response only. These experiments demonstrate the feasibility of parenteral immunization against H. pylori and suggest that an appropriate balance between Th1 and Th2 type responses is required to achieve complete protection.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(97)00258-2