Prevention of central venous catheter associated thrombosis using minidose warfarin in patients with haematological malignancies

Thrombosis is a well‐recognized complication following insertion of central venous catheters and is associated with significant morbidity. In an attempt to reduce line‐associated thrombosis, 108 consecutive patients with haematological malignancies were commenced on prophylactic ‘minidose’ warfarin,...

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Bibliographic Details
Published in:British journal of haematology 1998-06, Vol.101 (3), p.483-486
Main Authors: Boraks, Paul, Seale, James, Price, Jane, Bass, Gilda, Ethell, Mark, Keeling, David, Mahendra, Prem, Baglin, Trevor, Marcus, Robert
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anticoagulants - administration & dosage
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Catheterization, Central Venous - adverse effects
Catheters, Indwelling - adverse effects
central venous catheter
Emergency and intensive care: techniques, logistics
Hematologic Neoplasms - drug therapy
Hematology
Humans
Intensive care medicine
Medical sciences
Perfusions. Catheterizations. Hyperbaric oxygenotherapy
Pharmacology. Drug treatments
Retrospective Studies
Subclavian Vein
thrombosis
Thrombosis - prevention & control
Time Factors
warfarin
Warfarin - administration & dosage
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Summary:Thrombosis is a well‐recognized complication following insertion of central venous catheters and is associated with significant morbidity. In an attempt to reduce line‐associated thrombosis, 108 consecutive patients with haematological malignancies were commenced on prophylactic ‘minidose’ warfarin, 1 mg/d, at the time of line insertion. This group of patients were compared with a historic group of 115 consecutive patients who had not received warfarin. Clinically‐suspected venous thrombosis was confirmed by Doppler ultrasound or venography. Patients taking prophylactic warfarin had their prothrombin time measured three times per week with the aim of maintaining an INR
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1998.00732.x