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Prevention of central venous catheter associated thrombosis using minidose warfarin in patients with haematological malignancies
Thrombosis is a well‐recognized complication following insertion of central venous catheters and is associated with significant morbidity. In an attempt to reduce line‐associated thrombosis, 108 consecutive patients with haematological malignancies were commenced on prophylactic ‘minidose’ warfarin,...
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| Published in: | British journal of haematology 1998-06, Vol.101 (3), p.483-486 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4192-46d1a8b1560efed693812f89ff8a24354e62234ed5828affceca40e88b7d0a083 |
| container_end_page | 486 |
| container_issue | 3 |
| container_start_page | 483 |
| container_title | British journal of haematology |
| container_volume | 101 |
| creator | Boraks, Paul Seale, James Price, Jane Bass, Gilda Ethell, Mark Keeling, David Mahendra, Prem Baglin, Trevor Marcus, Robert |
| description | Thrombosis is a well‐recognized complication following insertion of central venous catheters and is associated with significant morbidity. In an attempt to reduce line‐associated thrombosis, 108 consecutive patients with haematological malignancies were commenced on prophylactic ‘minidose’ warfarin, 1 mg/d, at the time of line insertion. This group of patients were compared with a historic group of 115 consecutive patients who had not received warfarin. Clinically‐suspected venous thrombosis was confirmed by Doppler ultrasound or venography. Patients taking prophylactic warfarin had their prothrombin time measured three times per week with the aim of maintaining an INR |
| doi_str_mv | 10.1046/j.1365-2141.1998.00732.x |
| format | article |
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In an attempt to reduce line‐associated thrombosis, 108 consecutive patients with haematological malignancies were commenced on prophylactic ‘minidose’ warfarin, 1 mg/d, at the time of line insertion. This group of patients were compared with a historic group of 115 consecutive patients who had not received warfarin. Clinically‐suspected venous thrombosis was confirmed by Doppler ultrasound or venography. Patients taking prophylactic warfarin had their prothrombin time measured three times per week with the aim of maintaining an INR < 1.6. Five (5%) of the 108 patients who received minidose warfarin developed a thrombosis, at a median of 72 d (range 5–166) from the time of catheter insertion. In the 115 patients who were not anticoagulated 15 (13%) developed a catheter‐associated thrombosis at a median of 16 d (range 1–35). There was a significant reduction in line‐associated thrombosis in patients receiving warfarin (P = 0.03). These data suggest that minidose warfarin reduces the incidence of central venous catheter related thrombosis in patients with haematological malignancies.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.1998.00732.x</identifier><identifier>PMID: 9633891</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, U.K. and Cambridge, USA: Blackwell Publishers</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anticoagulants - administration & dosage ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Catheterization, Central Venous - adverse effects ; Catheters, Indwelling - adverse effects ; central venous catheter ; Emergency and intensive care: techniques, logistics ; Hematologic Neoplasms - drug therapy ; Hematology ; Humans ; Intensive care medicine ; Medical sciences ; Perfusions. Catheterizations. Hyperbaric oxygenotherapy ; Pharmacology. Drug treatments ; Retrospective Studies ; Subclavian Vein ; thrombosis ; Thrombosis - prevention & control ; Time Factors ; warfarin ; Warfarin - administration & dosage</subject><ispartof>British journal of haematology, 1998-06, Vol.101 (3), p.483-486</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Jun 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4192-46d1a8b1560efed693812f89ff8a24354e62234ed5828affceca40e88b7d0a083</citedby><cites>FETCH-LOGICAL-c4192-46d1a8b1560efed693812f89ff8a24354e62234ed5828affceca40e88b7d0a083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2263019$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9633891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boraks, Paul</creatorcontrib><creatorcontrib>Seale, James</creatorcontrib><creatorcontrib>Price, Jane</creatorcontrib><creatorcontrib>Bass, Gilda</creatorcontrib><creatorcontrib>Ethell, Mark</creatorcontrib><creatorcontrib>Keeling, David</creatorcontrib><creatorcontrib>Mahendra, Prem</creatorcontrib><creatorcontrib>Baglin, Trevor</creatorcontrib><creatorcontrib>Marcus, Robert</creatorcontrib><title>Prevention of central venous catheter associated thrombosis using minidose warfarin in patients with haematological malignancies</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Thrombosis is a well‐recognized complication following insertion of central venous catheters and is associated with significant morbidity. In an attempt to reduce line‐associated thrombosis, 108 consecutive patients with haematological malignancies were commenced on prophylactic ‘minidose’ warfarin, 1 mg/d, at the time of line insertion. This group of patients were compared with a historic group of 115 consecutive patients who had not received warfarin. Clinically‐suspected venous thrombosis was confirmed by Doppler ultrasound or venography. Patients taking prophylactic warfarin had their prothrombin time measured three times per week with the aim of maintaining an INR < 1.6. Five (5%) of the 108 patients who received minidose warfarin developed a thrombosis, at a median of 72 d (range 5–166) from the time of catheter insertion. In the 115 patients who were not anticoagulated 15 (13%) developed a catheter‐associated thrombosis at a median of 16 d (range 1–35). There was a significant reduction in line‐associated thrombosis in patients receiving warfarin (P = 0.03). These data suggest that minidose warfarin reduces the incidence of central venous catheter related thrombosis in patients with haematological malignancies.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anticoagulants - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Catheterization, Central Venous - adverse effects</subject><subject>Catheters, Indwelling - adverse effects</subject><subject>central venous catheter</subject><subject>Emergency and intensive care: techniques, logistics</subject><subject>Hematologic Neoplasms - drug therapy</subject><subject>Hematology</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Perfusions. Catheterizations. Hyperbaric oxygenotherapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Retrospective Studies</subject><subject>Subclavian Vein</subject><subject>thrombosis</subject><subject>Thrombosis - prevention & control</subject><subject>Time Factors</subject><subject>warfarin</subject><subject>Warfarin - administration & dosage</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqNUUuLFDEQDqKss6s_QQgi3rrNox8JeHEX11UW9KDnUJOuzGTo7oxJt7N786ebdoY5eBICKep7pFIfIZSzkrOqebcruWzqQvCKl1xrVTLWSlE-PCGrM_CUrFhuF1mgnpPLlHaMcclqfkEudCOl0nxFfn-L-AvHyYeRBkdtLiP0NLfCnKiFaYsTRgopBethwo5O2xiGdUg-0Tn5cUMHP_ouJKQHiA6iH2k-e5h89kr04Kct3QIOMIU-bLzN7gP0fjPCaD2mF-SZgz7hy9N9RX7cfvx-c1fcf_30-ebDfWErrkVRNR0HteZ1w9Bh12ipuHBKO6dAVLKusBFCVtjVSihwzqKFiqFS67ZjwJS8Im-PvvsYfs6YJjP4ZLHvYcT8VdNqXbVc6Ux8_Q9xF-Y45tkM16pum0osbupIsjGkFNGZffQDxEfDmVkSMjuzBGGWIMySkPmbkHnI0lcn_3k9YHcWniLJ-JsTDikvy8VlT-lME6KRjC9jvj_SDr7Hx_9-3lx_ucuF_AP6Gq6s</recordid><startdate>199806</startdate><enddate>199806</enddate><creator>Boraks, Paul</creator><creator>Seale, James</creator><creator>Price, Jane</creator><creator>Bass, Gilda</creator><creator>Ethell, Mark</creator><creator>Keeling, David</creator><creator>Mahendra, Prem</creator><creator>Baglin, Trevor</creator><creator>Marcus, Robert</creator><general>Blackwell Publishers</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199806</creationdate><title>Prevention of central venous catheter associated thrombosis using minidose warfarin in patients with haematological malignancies</title><author>Boraks, Paul ; Seale, James ; Price, Jane ; Bass, Gilda ; Ethell, Mark ; Keeling, David ; Mahendra, Prem ; Baglin, Trevor ; Marcus, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4192-46d1a8b1560efed693812f89ff8a24354e62234ed5828affceca40e88b7d0a083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anticoagulants - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Catheterization, Central Venous - adverse effects</topic><topic>Catheters, Indwelling - adverse effects</topic><topic>central venous catheter</topic><topic>Emergency and intensive care: techniques, logistics</topic><topic>Hematologic Neoplasms - drug therapy</topic><topic>Hematology</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Perfusions. Catheterizations. Hyperbaric oxygenotherapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Retrospective Studies</topic><topic>Subclavian Vein</topic><topic>thrombosis</topic><topic>Thrombosis - prevention & control</topic><topic>Time Factors</topic><topic>warfarin</topic><topic>Warfarin - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boraks, Paul</creatorcontrib><creatorcontrib>Seale, James</creatorcontrib><creatorcontrib>Price, Jane</creatorcontrib><creatorcontrib>Bass, Gilda</creatorcontrib><creatorcontrib>Ethell, Mark</creatorcontrib><creatorcontrib>Keeling, David</creatorcontrib><creatorcontrib>Mahendra, Prem</creatorcontrib><creatorcontrib>Baglin, Trevor</creatorcontrib><creatorcontrib>Marcus, Robert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boraks, Paul</au><au>Seale, James</au><au>Price, Jane</au><au>Bass, Gilda</au><au>Ethell, Mark</au><au>Keeling, David</au><au>Mahendra, Prem</au><au>Baglin, Trevor</au><au>Marcus, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of central venous catheter associated thrombosis using minidose warfarin in patients with haematological malignancies</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>1998-06</date><risdate>1998</risdate><volume>101</volume><issue>3</issue><spage>483</spage><epage>486</epage><pages>483-486</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Thrombosis is a well‐recognized complication following insertion of central venous catheters and is associated with significant morbidity. In an attempt to reduce line‐associated thrombosis, 108 consecutive patients with haematological malignancies were commenced on prophylactic ‘minidose’ warfarin, 1 mg/d, at the time of line insertion. This group of patients were compared with a historic group of 115 consecutive patients who had not received warfarin. Clinically‐suspected venous thrombosis was confirmed by Doppler ultrasound or venography. Patients taking prophylactic warfarin had their prothrombin time measured three times per week with the aim of maintaining an INR < 1.6. Five (5%) of the 108 patients who received minidose warfarin developed a thrombosis, at a median of 72 d (range 5–166) from the time of catheter insertion. In the 115 patients who were not anticoagulated 15 (13%) developed a catheter‐associated thrombosis at a median of 16 d (range 1–35). There was a significant reduction in line‐associated thrombosis in patients receiving warfarin (P = 0.03). These data suggest that minidose warfarin reduces the incidence of central venous catheter related thrombosis in patients with haematological malignancies.</abstract><cop>Oxford, U.K. and Cambridge, USA</cop><pub>Blackwell Publishers</pub><pmid>9633891</pmid><doi>10.1046/j.1365-2141.1998.00732.x</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0007-1048 |
| ispartof | British journal of haematology, 1998-06, Vol.101 (3), p.483-486 |
| issn | 0007-1048 1365-2141 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anticoagulants - administration & dosage Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Catheterization, Central Venous - adverse effects Catheters, Indwelling - adverse effects central venous catheter Emergency and intensive care: techniques, logistics Hematologic Neoplasms - drug therapy Hematology Humans Intensive care medicine Medical sciences Perfusions. Catheterizations. Hyperbaric oxygenotherapy Pharmacology. Drug treatments Retrospective Studies Subclavian Vein thrombosis Thrombosis - prevention & control Time Factors warfarin Warfarin - administration & dosage |
| title | Prevention of central venous catheter associated thrombosis using minidose warfarin in patients with haematological malignancies |
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