Contact activation of blood coagulation: trigger properties and hysteresis. Kinetic recognition of foreign surfaces upon contact activation of blood coagulation: a hypothesis

A mathematical model of contact activation of blood coagulation was developed and analysed. The model variables are concentrations of factor XIIa, kallikrein and activated high-molecular-weight kininogen. Concentrations of active factors were shown to depend on the activating signal value in a hyste...

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Bibliographic Details
Published in:Journal of theoretical biology 1998-03, Vol.191 (2), p.213-219
Main Authors: Pokhilko, A V, Ataullakhanov, F I
Format: Article
Language:English
Subjects:
Blood Coagulation
Factor XIIa - physiology
Hemorheology
Humans
Kallikreins - physiology
Kininogen, High-Molecular-Weight - physiology
Mathematics
Models, Biological
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Summary:A mathematical model of contact activation of blood coagulation was developed and analysed. The model variables are concentrations of factor XIIa, kallikrein and activated high-molecular-weight kininogen. Concentrations of active factors were shown to depend on the activating signal value in a hysteretic manner. Within a range of relatively small signals, two (activated and non-activated) stable states coexist (bistability). Signals of the natural environment (surfaces of endothelial and blood cells) seem to be in the range of bistability; therefore, contact activation that persists for a short time can induce a transition of the system to the activated state, and, correspondingly, the formation of a clot. The system cannot return to the initial state, which is characterized by low activation levels, until the activating signals decrease significantly below those present in the circulation.
ISSN:0022-5193
DOI:10.1006/jtbi.1997.0584