ISOLATION OF CEPAFUNGINS I, II AND III FROM PSEUDOMONAS SPECIES

New acylpeptide antibiotics named cepafungins I, II and III were isolated from the culture broth of a strain identified as Pseudomonas sp. These antibiotics are neutral substances, soluble in aqueous alcohols and dimethyl sulfoxide, and show UV maxima at 260.5nm. The IR spectra indicated these to be...

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Bibliographic Details
Published in:Journal of antibiotics 1990/07/25, Vol.43(7), pp.783-787
Main Authors: SHOJI, JUN'ICHI, HINOO, HIROSHI, KATO, TOSHIYUKI, HATTORI, TERUO, HIROOKA, KEIICHIRO, TAWARA, KATSUYA, SHIRATORI, OSAMU, TERUI, YOSHIHIRO
Format: Article
Language:English
Subjects:
Animals
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, Antineoplastic - biosynthesis
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antibiotics, Antineoplastic - therapeutic use
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antifungal Agents - biosynthesis
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Applied microbiology
Biological and medical sciences
Chromatography, High Pressure Liquid
Fundamental and applied biological sciences. Psychology
Fungi - drug effects
Leukemia L1210 - drug therapy
Leukemia P388 - drug therapy
Leukemia, Experimental - drug therapy
Magnetic Resonance Spectroscopy
Melanoma, Experimental - drug therapy
Mice
Microbiology
Peptides, Cyclic - biosynthesis
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Peptides, Cyclic - therapeutic use
Pseudomonas - classification
Pseudomonas - metabolism
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Yeasts - drug effects
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Summary:New acylpeptide antibiotics named cepafungins I, II and III were isolated from the culture broth of a strain identified as Pseudomonas sp. These antibiotics are neutral substances, soluble in aqueous alcohols and dimethyl sulfoxide, and show UV maxima at 260.5nm. The IR spectra indicated these to be peptides. Molecular formulas C28H46N4O6, C27H44N4O6 and C26H42N4O6 for cepafungins I, II and III were indicated by elemental analysis and SI-MS. Cepafungins exhibited inhibitory activity against yeast and fungi, and antitumor activity against P388 leukemia in mice.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.43.783