Monte Carlo-Assisted Voxel Source Kernel Method (MAVSK) for Internal Beta Dosimetry

A method is described for the determination of patient-specific organ beta doses given a known cumulated internal radioactivity distribution. A voxel source kernel for 90Y analogous to the point source function was simulated. Dose to each organ of interest could then be estimated by convolving the v...

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Bibliographic Details
Published in:Nuclear medicine and biology 1998-05, Vol.25 (4), p.423-433
Main Authors: Liu, An, Williams, Lawrence E., Wong, Jeffrey Y.C., Raubitschek, Andrew A.
Format: Article
Language:English
Subjects:
Absorbed beta dose
Applied radiobiology (equipment, dosimetry...)
Biological and medical sciences
Biological effects of radiation
Fundamental and applied biological sciences. Psychology
Humans
Monte Carlo Method
Neoplasms - radiotherapy
Radioimmunotherapy
Radioimmunotherapy - methods
Radiotherapy Planning, Computer-Assisted
Tissues, organs and organisms biophysics
Y-90
Yttrium Radioisotopes
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Summary:A method is described for the determination of patient-specific organ beta doses given a known cumulated internal radioactivity distribution. A voxel source kernel for 90Y analogous to the point source function was simulated. Dose to each organ of interest could then be estimated by convolving the voxel source kernel with the patient’s 3-D volume with known radioactivity assigned to each voxel. The dose calculation on eight organs took less than 1 min per patient using a Sun Sparc10 workstation.
ISSN:0969-8051
1872-9614
DOI:10.1016/S0969-8051(98)00002-X