Pancreatic cancer resection in elderly patients

Background Pancreatic cancer resection is considered a high‐risk procedure in patients aged 70 years or older. Methods Some 398 patients with pancreatic adenocarcinoma, observed between 1990 and 1995, were reviewed. Operative outcome and survival of 33 patients aged 70 years or more were compared wi...

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Bibliographic Details
Published in:British journal of surgery 1998-05, Vol.85 (5), p.607-610
Main Authors: DI Carlo, V., Balzano, G., Zerbi, A., Villa, E.
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Eating
Humans
Liver, biliary tract, pancreas, portal circulation, spleen
Medical sciences
Middle Aged
Multivariate Analysis
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Pancreaticoduodenectomy - methods
Pancreaticoduodenectomy - mortality
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Survival Analysis
Treatment Outcome
Weight Gain
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Summary:Background Pancreatic cancer resection is considered a high‐risk procedure in patients aged 70 years or older. Methods Some 398 patients with pancreatic adenocarcinoma, observed between 1990 and 1995, were reviewed. Operative outcome and survival of 33 patients aged 70 years or more were compared with findings in 85 younger patients who underwent resection. Results Resectability was not significantly different between the elderly and younger patients; neither were mortality or overall morbidity. However, patients aged 70 years or more had more relaparotomies (P < 0·01) and more haemorrhagic complications (P < 0·001). Nutritional recovery after resection was satisfying even for elderly patients (body‐weight gain and increase in serum albumin concentrations, P < 0·05). Univariate analysis showed a moderately poorer survival in the elderly (P = 0·09). Multivariate analysis demonstrated that tumour diameter, grading and Union Internacional Contra la Cancrum stage were independent prognostic factors, whereas age was not. Conclusion Patients aged 70 years or more can benefit from pancreatic cancer resection similarly to younger patients. © 1998 British Journal of Surgery Society Ltd
ISSN:0007-1323
1365-2168
DOI:10.1046/j.1365-2168.1998.00685.x