Once versus twice daily injections of growth hormone in children with idiopathic short stature

• Published in: Acta Paediatrica 1998-05, Vol.87 (5), p.518-520
• Main Authors: Phillip, M, Hershkovitz, E, Belotserkovsky, O, Leiberman, E, Limoni, Y, Zadik, Z
• Format: Article
• Language: English
• Subjects: Age Determination by Skeleton; Biological and medical sciences; Body Height; Child; Dosage; Drug Administration Schedule; Female; Growth Disorders - drug therapy; growth hormone; Growth Hormone - administration & dosage; Hormones. Endocrine system; Human Growth Hormone - deficiency; Humans; Injections; Insulin-Like Growth Factor I - metabolism; Male; Medical sciences; Pharmacology. Drug treatments; short stature; Treatment Outcome
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/j.1651-2227.1998.tb01496.x

The aim of this study was to compare the growth response of 22 short pre‐pubertal children without growth hormone deficiency, treated with a single daily growth hormone injection (group A), to the growth response of 27 similar children, treated with the same daily dose divided into 2 subcutaneous injections per day (group B), for 1 y, in a randomized study. GH treatment significantly promoted growth parameters, height standard deviation score and height velocity standard deviation score in both groups. Serum insulin‐like growth factor I was also increased. There were no significant differences in growth response, serum IGF‐I levels, or the advance in bone age between the two study groups after 1 y of GH therapy. We conclude that twice daily s.c. growth hormone injections provide no advantages over once daily injection of the same dose in promoting the linear growth of short children without growth hormone deficiency.