Two avian H10 influenza A virus strains with different pathogenicity for mink (Mustela vison)

We compared two strains of avian influenza A viruses of subtype H10 by exposing mink to aerosols of A/mink/Sweden/3,900/84 (H10N4) naturally pathogenic for mink, or A/chicken/Germany/N/49, (H10N7). Lesions in the respiratory tract during the first week after infection were studied and described. Bot...

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Bibliographic Details
Published in:Archives of virology 1998-01, Vol.143 (4), p.653-666
Main Authors: Englund, L, Hard Af Segerstad, C
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - analysis
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Influenza
Influenza A virus
Influenza A virus - pathogenicity
Lung - virology
Male
Microbiology
Mink - virology
Mustela vison
Nasal Mucosa - virology
Orthomyxoviridae Infections - physiopathology
Orthomyxoviridae Infections - veterinary
Orthomyxoviridae Infections - virology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Species Specificity
Vaccines
Virology
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Summary:We compared two strains of avian influenza A viruses of subtype H10 by exposing mink to aerosols of A/mink/Sweden/3,900/84 (H10N4) naturally pathogenic for mink, or A/chicken/Germany/N/49, (H10N7). Lesions in the respiratory tract during the first week after infection were studied and described. Both virus strains caused inflammatory reactions in the lungs and antibody production in exposed mink but only mink/84 virus was reisolated. The lesions caused by mink/84 virus were more severe with higher area density of pneumonia, lower daily weight gain, and more virus in the tissues detected by immunohistochemistry. The results indicate that mink/84 (H10N4), but not chicken/49 virus (H10N7), established multiple cycle replication in infected cells in the mink.
ISSN:0304-8608
1432-8798
DOI:10.1007/s007050050321