A novel system of peptidergic regulation

Systematic analysis of structure and biological activity of peptide components of tissue extracts and biological fluids allows us to formulate a novel concept of a peptidergic regulatory system, complementary to the conventional regulatory systems (i.e. nervous, endocrine and paracrine systems). Acc...

Full description

Saved in:
Bibliographic Details
Published in:FEBS Letters 1998-05, Vol.428 (1), p.7-12
Main Authors: Karelin, Andrei A, Blishchenko, Elena Yu, Ivanov, Vadim T
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biologically active peptide
Endopeptidases - metabolism
Humans
Molecular Sequence Data
Peptides - metabolism
Peptides - physiology
Proteins - metabolism
Proteolysis
Tissue homeostasis
Tissue-specific peptide pool
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Systematic analysis of structure and biological activity of peptide components of tissue extracts and biological fluids allows us to formulate a novel concept of a peptidergic regulatory system, complementary to the conventional regulatory systems (i.e. nervous, endocrine and paracrine systems). According to that concept, the proteolytic degradation of tissue proteins carried out by a specific and regulated system of tissue-specific enzymes and protein substrates gives rise to a large group of peptides, which we define as tissue-specific peptide pool. As a result, functional proteins provide their proteolytically derived fragments for maintaining tissue homeostasis.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(98)00486-4