Role of cholecystokinin in bombesin- and meal-stimulated pancreatic polypeptide secretion in dogs

• Published in: Digestive diseases and sciences 1990-09, Vol.35 (9), p.1073-1077
• Main Authors: JANSEN, J. B. M. J, DE JONG, A. J. L, SINGER, M. V, NIEBEL, W, ROVATI, L. C, LAMBERS, C. B. H. W
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Bombesin; Ceruletide; Cholecystokinin - physiology; Dogs; Female; Food; Fundamental and applied biological sciences. Psychology; General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions; Pancreatic Polypeptide - metabolism; Proglumide - analogs & derivatives; Receptors, Cholecystokinin - antagonists & inhibitors; Vertebrates: endocrinology
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/BF01537577

This study was undertaken to delineate the role of cholecystokinin (CCK) in bombesin- and meal-stimulated pancreatic polypeptide (PP) secretion in seven conscious dogs by studying: (1) the stimulatory effect of similar plasma levels of CCK induced by a meal and infusions of bombesin and the synthetic CCK analog cerulein on plasma PP, and (2) the inhibition of PP secretion by the CCK-receptor antagonist CR-1409 during these three stimuli. The stimulation of PP secretion during bombesin (11.0 +/- 1.6 nM/hr) and after the meal (8.9 +/- 2.0 nM/hr) were significantly (P less than 0.05) greater than during infusion of the CCK analog cerulein (2.7 +/- 0.4 nM/hr). CR-1409 significantly inhibited the bombesin- and meal-stimulated PP secretion to 2.0 +/- 0.4 nM/hr (81%; P less than 0.05) and 3.1 +/- 1.2 nM/hr (47%; P less than 0.05), respectively, while the cerulein-stimulated PP release was almost abolished to 0.2 +/- 0.1 nM/hr (93%; P less than 0.05) by the drug. These findings point to an important role for CCK in the regulation of bombesin- and meal-stimulated PP secretion.