Dopamine in gastrointestinal disease

Dopamine is an important enteric neuromodulator. Herein we review the data that support a role for dopaminergic involvement in experimental duodenal and gastric ulceration; gastric, pancreatic, and duodenal secretion; gastrointestinal motility; and gastric and intestinal submucosal blood flow regula...

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Bibliographic Details
Published in:Digestive diseases and sciences 1990-09, Vol.35 (9), p.1153-1161
Main Authors: GLAVIN, G. B, SZABO, S
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dopamine - physiology
Duodenal Ulcer - etiology
Gastric Acid - metabolism
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Motility - physiology
Humans
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Other diseases. Semiology
Stomach Ulcer - etiology
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Summary:Dopamine is an important enteric neuromodulator. Herein we review the data that support a role for dopaminergic involvement in experimental duodenal and gastric ulceration; gastric, pancreatic, and duodenal secretion; gastrointestinal motility; and gastric and intestinal submucosal blood flow regulation. There also is support for a role for dopamine and dopamimetic agents in the treatment of certain experimental gastrointestinal diseases because some highly selective dopamine agonists are gastroprotective when given either parenterally or centrally. Based upon these observations, we suggest that dopamine is a key element of the "brain-gut axis" and represents a potentially important target for pharmacotherapeutic exploitation.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01537589